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Enhanced Long-Term Care of Severe Respiratory Failure

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
49532
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
1R43HL064528-01
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Compact Membrane Systems, Inc.
335 Water Street Newport, DE 19804-2410
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2004
Title: Enhanced Long-Term Care of Severe Respiratory Failure
Agency: HHS
Contract: 2R44HL064528-02
Award Amount: $1,010,459.00
 

Abstract:

DESCRIPTION (provided by applicant): Current management of acute respiratory distress syndrome (ARDS) is suboptimal. Arteriovenous carbon dioxide removal (AVCO2R) combined with mild oxygen ventilation has shown promise. AVCO2R is mild pumpless technique using low-pressure drop membrane oxygenators, which reduces labor, cost, complexity and patient stress. While AVCO2R works for short durations, ARDS therapy must operate continuously for weeks. Phase I successfully demonstrated CMS non-porous membranes significantly enhance AVCO2R membrane long term wet-out resistance while maintaining carbon dioxide removal membrane modules fluid dynamics. Working closely with University of Texas (UT) we completed short-term in-vivo testing on 10 sheep using UT sheep model. In-vivo results showed CMS AVCO2R system compared favorably to control. Long term in-vivo testing further supported CMS new membrane technology. Phase II will build upon Phase I feasibility success and first optimize membrane module fabrication. Working with UT we will do extensive in-vitro testing and then perform numerous (40+) long-term sheep studies. CMS has numerous industrial partners assisting in Phase II system fabrication and subsequent evaluation. These relationships will help Phase II plus identifying appropriate commercialization partners.

Principal Investigator:

Stuart M. Nemser
3029997996
stuart.nemser@compactmembrane.com

Business Contact:

Nadine Cragg-lester
3029997996
NLESTER@COMPACTMEMBRANE.COM
Small Business Information at Submission:

COMPACT MEMBRANE SYSTEMS, INC.
325 WATER STREET WILMINGTON, DE 18904

EIN/Tax ID: 510348256
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No