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Antimicrobial Dendrimers for Catheter Utilization

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
54461
Program Year/Program:
2001 / SBIR
Agency Tracking Number:
1R43DK060296-01
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Compact Membrane Systems, Inc.
335 Water Street Newport, DE 19804-2410
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2001
Title: Antimicrobial Dendrimers for Catheter Utilization
Agency: HHS
Contract: N/A
Award Amount: $100,000.00
 

Abstract:

Intravenous access is an essential part of successful therapy and comfort of hospital patients, nursing home residents and homebound patients. About 4% of homebound patients and over 100,000 nursing home residents require indwelling Foley Catheters. While catheters play an important part in medicine, their use is accompanied by the risk of catheter-associated infections (CAI). CAI is caused by pathogens adhering to the catheter surface, proliferating and producing a biofilm. In this program, Compact Membrane Systems (CMS) will develop a family of novel catheters containing non-leaching biocides. In Phase I CMS will demonstrate that these novel catheters are superior to existing catheters in their ability to reduce CAI and do not either leach into the body or cause immune complex activation. Specific tasks to demonstrate feasibility include fabrication of the novel catheters, demonstration of non-leaching catheter, in vitro and in vivo bactericidal activity, and preliminary engineering evaluation. Phase I feasibility will be demonstrated by showing superior performance to existing state of the art catheters and controls that do not contain the non-leaching biocide. Phase I focus will be on central venous catheters with peritoneal dialysis catheters being evaluated at a later time. PROPOSED COMMERCIAL APPLICATIONS: Development of non-leaching biocidal catheter will provide value in numerous catheter applications by avoiding infections. Applications include central venous catheters and peritoneal dialysis catheters. Catheter infection can be potentially life threatening and costly.

Principal Investigator:

Nina M. Lamba

Business Contact:


3029997996
WWW.COMPACTMEMBRANE.COM
Small Business Information at Submission:

COMPACT MEMBRANE SYSTEMS, INC.
325 WATER ST WILMINGTON, DE 19804

EIN/Tax ID: 510348256
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No