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HIGH THROUGH-PUT DISCOVERY OF MALARIA DRUG TARGETS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60528
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
AI051776
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
COMPLEGEN, INC.
1124 COLUMBIA ST, STE 662 SEATTLE, WA 98104-2050
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: HIGH THROUGH-PUT DISCOVERY OF MALARIA DRUG TARGETS
Agency: HHS
Contract: 1R43AI051776-01
Award Amount: $284,047.00
 

Abstract:

DESCRIPTION (Provided by applicant): Emerging and re-emerging infectious diseases are some of the most important contributors to pain, suffering and poverty in the developing world. For parasitic diseases in general, vaccines are nonexistent and none are likely to have a significant impact in the foreseeable future. In the case of malaria, without a vaccine on the horizon and an increasing prevalence of resistance to commonly used therapeutic drugs, the need for additional anti-malarial drug development is obvious. However, several factors, including increased cost of development, have lead to the retreat of most pharmaceutical companies from the development of new anti-malarial therapeutics. The research and development described in this proposal utilizes a new cost effective approach to anti-malarial drug target discovery. We will use a comparative approach to identify potential therapeutic targets common to Plasmodium falciparum, Toxoplasma gondii and Eimeria tenella. This work will form the basis for a future phase II application, which will use the reagents developed here to identify broad spectrum apicomplexan specific inhibitor compounds.

Principal Investigator:

John T. Swindle
2064478076
JSWINDLE@COMPLEGEN.COM

Business Contact:

Joel Hedgpeth
2064478076
Small Business Information at Submission:

COMPLEGEN, INC.
COMPLEGEN, INC. 1124 COLUMBIA ST, STE 662 SEATTLE, WA 98104

EIN/Tax ID: 943343600
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No