A two-dimensional photon-counting position encoder is proposed for position emission tomography (pet) 1. a method of controlling the spatial distribution of photons from bismuth germanate scintillators, 2. the use of all-digital photon counting for processing the photomultiplier signal, and 3. the… More

An automatic synthesis module for the production of f18-fluorodeoxyglucose (fdg) is planned. this meta- bolic analog has been used extensively in the positron emission tomographic (pet) studies of cerebral and and myocardial metabolic rates and is a highly desir- able agent to be readily available… More

The development of an automated synthesis module (asm) for the production of oxygen-15 labeled butanol is proposed. oxygen-15labeled butanol is the ""gold standard'' for cerebral blood flow measurement but because of the short half-life of oxygen-15 (2 minutes) the synthesis must be performed in a… More

We propose to develop an automated chemistry system to work from the target of the cti medical cyclotron. the synthesis will be 16-betamethoxy-17-alpha-iodovinylestradiol. the material has proven to be one of the most active steroid receptor site agents to date and should prove valuable for the… More

A new two-dimensional position encoder is proposed for pet with position resolution better than 3 millimeters. the new detector includes 32 bismuth germanate (bgo) scintillation crystals mounted on a light guide. the light guide provides a square root separation of the light distribution from each… More

An automatic synthesis module for the production of f-18 fluorodeoxyglucose is proposed. this metabolic analog has been extensively used in the positron emission tomographic investigations of cerebral and myocardial metabolic rates, and is a highly desirable agent to be readily available in a pet… More

A new two-dimensional position encoder is planned for pet with position resolution better than 3 mm. the new detector includes 32 bismuth germanate (bgo) scintil- lation crystals mounted on a light guide. the light guide provides a square root separation of the light distributed from each crystal.… More

During a positron emission tomography (pet) scan, movement by the subject of more than 1 mm will cause noticeable blurring of the image. movement will also cause artifacts to be introduced into the image because the matrix for correcting for gamma-ray absorption is determined for a specific… More

The development of an automated synthesis module (asm) for the production of nitrogen-13-labeled octylamine is proposed. nitrogen-13-la-beled octylamine is a promising lung-imaging agent. however, because of the short half-life of nitrogen-13 (10 minutes), the synthesis must beperformed in a rapid,… More

This project is aimed at designing a light weight and compact negative ion cyclotron using a superconducting magnet. the proposed cyclotron will cost 25% less than existing resistive magnet cyclotrons, will occupy 50% less space, and will weigh approximately 4000 lbs compared with 40,000 lbs for the… More

A single-chip engine for tomographic reconstruction is proposed by computer technology and imaging, inc. the engine would be fabricated using current vlsi technology. such an engine can be replicated and used to implement a reconstruction processor. a processor using just eight of the vlsi engines… More

This study will investigate the feasibility of implementing a new architecture for part of the processing required to reconstruct images for positron emission tomography. implementing this new architecture for coincidence detectionin a very large scale integrated (vlsi) circuit should not only… More

The phase i effort will investigate the implementation of a general-purpose, single-chip constant-fraction discriminatorand single-chip or minimal-chip-set time-to-digital converter using advanced semicustom integrated-circuit technology. the goal of these new implementations is to achieve more… More

The research will lead to the development of a very high-resolution scintillation detector array for positron emission tomography (pet) imaging. two alternative schemes will be investigated to improve the image resolution and quantitative accuracy of pet. the first will be an advance to the current… More

A new detector consisting of a monolithic array of silicon avalanche photodiodes (APDs) coupled to a bismuth germanate (BGO) scintillator array will be fabricated and tested. The prototype detector array will be evaluated for its potential to be incorporated into a positron emission tomography (PET)… More

41235 November 21, 1996 CTI, Inc. The ability to image and quantify gene expression in vivo would create an important and powerful new tool for modern biology. Several techniques for imaging gene expression using positron emission tomography (PET) are… More

Not Available The proposed effort focuses on the need for enhanced analytical modeling approaches to characterize and understand fatigue crack initiation and growth in gas turbine engine intermetallics. It is recognized that the design of components subjected to fatigue cannot be based on average… More

DESCRIPTION (Verbatim from the Applicant's Abstract): We have demonstrated in Phase I that grid window supports for accelerator targets represent an improvement in terms of maximum operating pressure, area independence, and heat removal over convectively cooled designs.… More

DESCRIPTION (Verbatim from the Applicant's Abstract): We have demonstrated in Phase I that grid window supports for accelerator targets represent an improvement in terms of maximum operating pressure, area independence, and heat removal over convectively cooled designs.… More