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AN AUTOMATIC SYNTHESIS MODULE FOR THE PRODUCTION OF F-18 FLUORODEOXYGLUCOSE IS…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3034
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
3034
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
CTI SERVICES, INC.
810 INNOVATION DR KNOXVILLE, TN 37932
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: AN AUTOMATIC SYNTHESIS MODULE FOR THE PRODUCTION OF F-18 FLUORODEOXYGLUCOSE IS PROPOSED.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

AN AUTOMATIC SYNTHESIS MODULE FOR THE PRODUCTION OF F-18 FLUORODEOXYGLUCOSE IS PROPOSED. THIS METABOLIC ANALOG HAS BEEN EXTENSIVELY USED IN THE POSITRON EMISSION TOMOGRAPHIC INVESTIGATIONS OF CEREBRAL AND MYOCARDIAL METABOLIC RATES, AND IS A HIGHLY DESIRABLE AGENT TO BE READILY AVAILABLE IN A PET CENTER SETTING. MUCH WORK HAS BEEN EXPENDED ON FDG SYNTHESIS, BUT AN AUTOMATED, RELIABLE SYSTEM BEGINNING WITH THE HIGH YIELD OXYGEN-18 PROTON REACTION IS NOT AVAILABLE. THE INVESTIGATION WILL PROCEED ON 2 LEVELS: 1.FOCUS ON TARGET CHAMBER APPROACHES TO PRODUCE SYNTHETICALLY USEFUL (METAL ION-FREE) F18 AND 2.REFINEMENT OF AN EXISTING MANUAL SYNTHESIS APPARATUS INTO A SEMIAUTOMATIC SYNTHESIS MODULE. THE OXYGEN-18 ROUTE HAS THE ADVANTAGE OF ELIMINATING THE REQUIREMENT FOR HANDLING TOXIC, HIGHLY REACTIVE FLUORINE GAS AND WILL PRODUCE A HIGHER YIELD OF FLUORINE-18. THE SYNTHETIC REQUIREMENT FOR AQUEOUS F18-FLUORIDE, FREE FROM INTERFERING CATIONS, DICTATES THE NEED TO EXAMINE 2 TARGET CHAMBER CONFIGURATIONS: AN OXYGEN GAS TARGET WHICH CAN BE RECYCLED AND AN OXYGEN-18 WATER TARGET WHICH IS EASILY TRANSPORTED FROM CYCLOTRON TO SYNTHESIS SITE. CONCURRENTLY, THE FDG SYNTHESIS ROUTE UNDER USE AT UNIVERSITY OF WISCONSIN WILL BE REFINED FROM A REMOTE BUT MANUAL SYNTHESIS INTO A SEMIAUTOMATIC PROCESS.

Principal Investigator:

Maria straatmann
PRINCIPAL INVESTIGATOR
4155248844

Business Contact:

Small Business Information at Submission:

Computer Technology & Imaging
950 Gilman Street Berkeley, CA 94710

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No