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Keratin Biomaterials for Cranio-facial Tissue Engineering

Award Information

Agency:
Department of Defense
Branch:
Office of the Secretary of Defense
Award ID:
96854
Program Year/Program:
2010 / SBIR
Agency Tracking Number:
O093-H10-3014
Solicitation Year:
N/A
Solicitation Topic Code:
OSD 09-H10
Solicitation Number:
N/A
Small Business Information
KeraNetics, LLC
Richard Dean Research Building, Suite 168 391 Technology Way Winston-Salem, NC -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2010
Title: Keratin Biomaterials for Cranio-facial Tissue Engineering
Agency / Branch: DOD / OSD
Contract: W81XWH-10-C-0165
Award Amount: $99,260.00
 

Abstract:

The majority of personnel injured in OIF/OEF have suffered blast effects from IEDs. Blasts often cause cranio-facial trauma that is difficult to repair. There is a significant need to develop better platform technologies for these injuries and translate them into clinical and commercial use. A family of biomaterials derived from keratin proteins may provide a platform on which regenerative strategies can be built. Keratins have broad biocompatibility and can be formulated as films, foams, gels, fibers, or solid tissue constructs. One of the problems with many synthetic and naturally derived biomaterials is that they do not promote cell adhesion and migration into scaffolds that have weak cell-matrix interactions. Keratins have intrinsic cell-binding properties that can be exploited to offer potential new solutions to cranio-facial regeneration. This Phase I proposal seeks to perform initial testing of keratin materials using primary cell types relevant to cranio-facial tissues. Assessments will be made regarding cell attachment, proliferation, gene expression and other cell specific assays to validate that keratin materials provide a permissive extracellular matrix-like environment. Results will be used to tailor specific types of keratin proteins into biomaterial scaffolds for use in large animal cranio-facial defect studies to be conducted in Phase II.

Principal Investigator:

Luke Burnett
Senior Scientist
3362021307
luke.burnett@keranetics.com

Business Contact:

Kim Westmoreland
Co-Managing Director
3369186405
kim.westmoreland@keranetics.com
Small Business Information at Submission:

KeraNetics, LLC
1st Floor, Richard Dean Building 391 Technology Way Winston-Salem, NC 27101

EIN/Tax ID: 262789357
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No