USA flag logo/image

An Official Website of the United States Government

CYSTOLIC CA(2+) INOPHORES FOR FLUORESCENCE AND (19) F NMR

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7279
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7279
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
COVALENT ASSOC., INC.
541 NW 11th Street Corvallis, OR 97330 6018
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: CYSTOLIC CA(2+) INOPHORES FOR FLUORESCENCE AND (19) F NMR
Agency: HHS
Contract: N/A
Award Amount: $48,000.00
 

Abstract:

INTRACELLUAR CALCIUM IS CURRENTLY THE SUBJECT OF WIDESPREAD INTEREST AS A SECOND MESSENGER THAT TRIGGERS AND REGULATES CELL ACTIVATION. A SERIES OF IMPROVED CA(2+)-CHELATING AGENTS THAT CAN BE USED FOR NUCLEAR MAGNETIC RESONANCE (NMR) AND FLUORESCENCE IMAGING WILL BE SYNTHESIZED AND EVALUATED FOR THEIR ABSORPTION AND EMISSION CHARACTERISTICS AS WELL AS THEIR ABILITY TO BIND CA(2+). THE PROPOSED CA(2+) INDICATORS WILL HAVE IMPROVED OPTICAL CHARACTERISTICS OVER CURRENTLY USED QUIN2 AND INDO-1, WHICH THEY RESEMBLE STRUCTURALLY EXCEPT FOR THE FLUOROPHORE. IN ADDITION, THE INDICATOR WILL BE FLUORINE SUBSTITUTED FOR (19)F NMR DETECTION. THE CHELATOR CAN BE USED TO FOLLOW CHANGES IN INTRACELLULAR CALCIUM CONCENTRATION, CA(2+)I, AS A FUNCTION OF TIME IN RESPONSE TO VARIOUS PERTURBING INFLUENCES.

Principal Investigator:

Margaret e. langmuir phd
6179381140

Business Contact:

Small Business Information at Submission:

Covalent Associates Inc
52 Dragon Court Woburn, MA 01801

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No