Lipophilic Calcium Fluoroionophores
1 R43 GM50609-1,
We will synthesize and test new lipophilic fluorescent ionophores for measuring calcium ionconcentrations in aqueous solutions. The ionophores are designed to be soluble in synthetic membranesand to respond selectively to Ca2+ in a contacting aqueous solution by undergoing a shift in absorptionand emission to longer wavelengths. Theses compounds will be of primary interest for incorporating intoa fiber optic chemical sensor (FOCS). A FOCS device will be of use for determining the concentrationof calcium ion in biological fluids in vitro and ultimately in vivo. A device based on this design wouldbe valuable in the intensive care unit or other hospital facility.
Small Business Information at Submission:
Principal Investigator:Margaret Langmuir
Covalent Associates, Inc.
10 State Street Woburn, MA 01801
Number of Employees: