New Diode-Laser Excitable Probes for Hypoxia Detection

Award Information

Agency: Department of Health and Human Services	Branch: N/A	Award ID: 22026	Program Year/Program: 1993 / SBIR
Agency Tracking Number: 22026	Solicitation Year: N/A	Solicitation Topic Code: N/A	Solicitation Number: N/A

Small Business Information: COVALENT ASSOC., INC.
541 NW 11th Street Corvallis, OR 97330 6018
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Woman-Owned: No

Minority-Owned: No

HUBZone-Owned: No

Phase 1: Fiscal Year: 1993

Title: New Diode-Laser Excitable Probes for Hypoxia Detection

Agency: HHS

Contract: N/A

Award Amount: $50,000.00

Abstract:
We will synthesize and study fluorescent probes for hypoxic cells. The optical properties of the new compounds will be evaluated. Their ability to discriminate between hypoxic and oxic cells will be tested in cell cultures. These new probes will selectively bind to biomolecules in hypoxic cells. They will absorb in the 660-670 nm region to match the emission of newly available diode lasers. The long wavelength absorption, high molar extinction coefficients, and high quantum yields of the probe/biomolecule conjugates will allow sensitive detection of hypoxic cells. This will greatly improve the effectiveness of radiotherapy in cancer treatment.

Principal Investigator:
Jun-Rui Yang
6179381140

Business Contact:

Small Business Information at Submission:

Covalent Associates, Inc.
10 State Street Woburn, MA 01801

EIN/Tax ID:

DUNS: N/A

Number of Employees: N/A

Woman-Owned: No

Minority-Owned: No

HUBZone-Owned: No