USA flag logo/image

An Official Website of the United States Government

Fluorescent Indicators for Cytosolic Lithium Ion

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
22443
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
22443
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
COVALENT ASSOC., INC.
541 NW 11th Street Corvallis, OR 97330 6018
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1993
Title: Fluorescent Indicators for Cytosolic Lithium Ion
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

We propose to synthesize and test new fluorescent indicators for the lithium ion in aqueous solution. The indicators are designed to be water soluble and to respond selectively to Li+ by undergoing a shift in absorption and emission wavelengths. The proposed compounds will be of primary interest for determining the concentration of cytosolic Li+ and for monitoring any flux of Li+ in single cells acted on by neurotransmitters. The indicators will be of use to cell physiologists and neuroscientists studying the influence of Li+ on the phosphatidylinositol cycle implicated in the mechanism by which Li+ functions in the treatment of manic-depressive psychosis. The indicators may also be of use for measuring the concentration of Li+ in the serum of patients undergoing therapy.

Principal Investigator:

Christopher Blackburn
6179381140

Business Contact:

Small Business Information at Submission:

Covalent Associates, Inc.
10 State Street Woburn, MA 01801

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No