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Gsh Receptor Probes to Study Cns Development/Dysfunction

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
22375
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
22375
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
COVALENT ASSOC., INC.
541 NW 11th Street Corvallis, OR 97330 6018
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1995
Title: Gsh Receptor Probes to Study Cns Development/Dysfunction
Agency: HHS
Contract: N/A
Award Amount: $715,121.00
 

Abstract:

Preliminary evidence now exists that glutathione (GSH) acts as a neurotransmitter in the mammalian central nervous systems. Binding constants for receptor sites have been measured using radiolabeled GSH on synaptic membranes and on cultured astrocyte cells. There is evidence for GSH receptor sites in various other CNS structures as well. We will synthesize fluorescent GSH probes for the study of these receptor sites and measure their binding constants in competition with radiolabeled GSH. Fluorescence labeled probes with suitable binding constants will be used to study the distribution of binding sites in the CNS and other peripheral tissues and to examine second messenger (IP3) activation in cultured astrocytes. Fluorescent labeling on different GSH functional groups will also help elucidate the nature of the GSH receptor site.

Principal Investigator:

Margaret E. Langmuir
6179381140

Business Contact:

Small Business Information at Submission:

Covalent Associates, Inc.
10 State Street Woburn, MA 01801

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No