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Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
96230
Program Year/Program:
2010 / SBIR
Agency Tracking Number:
N43CO201000084
Solicitation Year:
N/A
Solicitation Topic Code:
NCI
Solicitation Number:
N/A
Small Business Information
NANOIVD, INC.
637 Lucas Avenue, Suite 550 Los Angeles, CA 90017
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2010
Title: Not Available
Agency: HHS
Contract: N43CO201000084
Award Amount: $182,050.00
 

Abstract:

Silicon nanowire (SiNW) electrical biosensing shows promise for point-of-care test (POCT) applications  which can lead to more rapid cancer diagnosis and early intervention.  Our goal is to increase the sensitivity of SiNW-based sensors through novel design and fabrication. We will  utilize the superlattice nanowire pattern transfer (SNAP) method to produce highly aligned arrays of SiNWs,  each 25 nm wide and 3 mm long. NW doping level will be optimized and sectioned into several individual  sensor arrays, electrical contacts to the NW sensors established, and each array integrated into a  microfluidic channel to demonstrate that a single-stranded complementary oligonucleotide on counter  electrode is able to significantly change the conductance of a SiNWs in saline solution when hybridized to a  primary DNA strand.  Proof of principle will be demonstrated by the reproducible detection of target species, K-ras mutated DNA  sequences spiked in saline. Sensitivity and specificity as well as reliability testing will be performed. For  sensitivity testing, 25 samples with and 25 without spiked target DNA sequence will be tested and  interpreted. For specificity, 25 non-target DNA sequence sample will be tested. For reliability testing, target  DNA spiked samples will be retested twice and at 24-hour intervals and reliability coefficients calculated.

Principal Investigator:

Sunnie Kim
3105291188
s.kim@nanoivd.com

Business Contact:

Small Business Information at Submission:

NANOIVD, INC.
NANOIVD, INC. 637 Lucas Avenue, Suite 550 Los Angeles, CA 90017

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No