This Small Business Innovation Research Phase I program proposed to develop an enabling electron source suitable for a wide range of application of optical devices, such as field-emission flat-panel displays and head-mounted displays, as well as for enabling compact, tunable infrared lasers,… More

50685-98-I Robust Zirconium Carbide and Hafnium Carbide Field Emitter Cathodes for Accelerator and Beams Applications--Creatv MicroTech, Inc., 11609 Lake Potomac Drive, Potomac, MD 20854-1221; (301) 983-1650 Dr. Cha-Mei Tang, Principal Investigator Dr. Cha-Mei Tang, Business Official DOE Grant No.… More

Not Available Achieving greater levels of independence for individuals with mental retardation depends upon a number of key skiffs that must be learned to a proficiency level. One of the significant barriers that exists for individuals with cognitive limitations is time management and adhering to a… More

Collimators determine the resolution and sensitivity of the gamma cameras used in planar scintigraphy and single photon emission computed tomography (SPECT) in nuclear medicine. We propose to develop deep x-ray lithography/electroplating method to fabricate collimators. This new method has the… More

Biosensors have wide applicability, such as medical diagnostics, infectious diseases, environmental sensing and food contamination, by detecting proteins, enzymes, bacteria, toxins, drugs, pollutants, DNA, etc. The development of better biosensors will have far-reaching societal impact, improving… More

DESCRIPTION (provided by applicant): This Phase I SBIR project will demonstrate an innovative cancer screening and diagnostic test based on the molecular tumor marker cancer specific proliferating cell nuclear antigen (csPCNA). A new compact device, the csPCNA Immunosensor, will be designed and… More

DESCRIPTION (provided by applicant): Mammography is currently the gold standard for breast screening. However, the positive predictive value (fraction of cases identified as positive by mammography that truly are positive) is only 20 - 25%. Thus the vast majority of breast biopsies performed are… More

DESCRIPTION (provided by investigator): This Small Business Innovation Research proposes to combine the best features of three different technologies: immunoassay, cell culture and real-time polymerase chain reaction (PCR), into one integrated test for environmental detection of the CDC Category A… More

DESCRIPTION (provided by applicant): Our food is a major source of illness. The Centers for Disease Control (CDC) estimates that food-borne diseases cause approximately 76 million incidents of illness, resulting in 325,000 hospitalizations and 5,000 deaths annually in the U.S. Known pathogens were… More

DESCRIPTION (provided by applicant): Neisseria gonorrhoeae, a pathogenic agent of gonorrhoeae, is the major cause of sexually transmitted diseases (STD) in the United States, and there is currently no effective vaccine. Previous investigations using several cell surface components have failed in… More

Enterohemorrhagic Escherichia coli (E. coli O157:H7) is a causative agent of food- and water-borne diseases. Newly developed rapid immunoassay- and PCR-based techniques have been used for detection of E. coli O157:H7 in water and food samples. However, they have proven inadequate, because of the… More

Clostridium botulinum neurotoxins (BoNT) are among the most poisonous substances known. Although production and dissemination of pure toxin is not trivial, it is highly feasible, making BoNT a potentially devastating bioweapon. Four serotypes A, B, E and F cause illness in humans. At present, the… More

DESCRIPTION (provided by applicant): Chronic lymphocytic leukemia (CLL) is a heterogeneous disease. Many patients never need treatment, whereas others have an aggressive clinical outcome with significantly reduced median survival. New treatments that can induce complete remission permit patients… More

DESCRIPTION (provided by applicant): Prion diseases are a family of fatal neurodegenerative diseases that are caused by infectious misfolded prion proteins (PrPSc) in both animals and humans. Prion diseases can occur spontaneously and can be contracted by multiple routes: consumption of contaminated… More

Illnesses due to waterborne pathogens are a substantial health risk, as seen in the E. coli O157:H7 outbreaks of 2006 that were traced to fecal contamination of fresh produce irrigation water. Additionally, there is the possibility of deliberate contamination of our water, and hence our food supply,… More

DESCRIPTION (provided by applicant): Breast cancer is the most common cancer among women in the United States and is second only to lung cancer as a cause of cancer-related death. Much of the reduced mortality over the past decade can be attributed to ear ly detection and timely medical… More

DESCRIPTION (provided by applicant): We propose a novel technology for detection of low abundance protein in body fluids, with initial application to a mental health biomarker. One of the most significant challenges facing biomarker discovery is the need t o separate high and low abundance proteins… More

DESCRIPTION (provided by applicant): Breast cancer is the most common cancer among women in the United States and is second only to lung cancer as a cause of cancer-related death. Much of the reduced mortality over the past decade can be attributed to ear ly detection and timely medical… More

This SBIR Phase I project will develop an automated in-line biosensor to monitor pathogens in treated wastewater. It is intended for farms and other small facilities. The focus is to include the sensor in package wastewater treatment systems developed by Spiralcat of Maryland for treating swine… More