Currently in the united states there are 360,000 small vessel implants and 100,000 peripheral vascular reconstructions annually. of this population needing vascular surgery, approximately 15 percent of the patients do not have vessels suitable for autografts. a prototype procedure has been developed… More

The worldwide potential market for ligament and tendon implants is in excess of 100,000 units annually. the currently available prosthetic implants are clinically unsatisfactory and autologous grafts may compromise the site of tissue origin. the long term objective of this project is to develop… More

With current fda-approved protocols for the cryopreservation of human red blood cells, the cells are treated with multimolar concentrations of glycerol, a permeating cryoprotectant. after thawing, extensive processing of red cells is required to remove the glycerol, prior to transfusion, to prevent… More

During the last 20 years, allograft heart valve transplantation in the united states has increased from about 50 to 2,000 per annum. because of this increased demand, particularly for pediatric cases, utilization of these cryopreserved heart valves is now limited by the supply of donated human… More

This study focuses on the use of antifreeze peptides in the development of an improved method for cryopreservation of bone marrow progenitor cells. recombinant antifreeze peptides have been found to inhibit migratory recrystalization during thawing of erythrocytes and to permit reduction in… More

Fibrin sealant has many applications in surgery. mixing and delivery of the major components, fibrinogen and thrombin, is currently achieved using two syringes or spray containers dispensed alternately or simultaneously to deliver fibrin sealant onto the wound site. these systems of delivery are… More

The major factor limiting more widespread utilization of allogeneic veins in arterial bypass procedures is the recipients' immune response. The intimal endothelial cells appear to be the focus of this immune response, which results in loss of the intimal lining of the vessel lumen during the first… More

Though allograft human aortic valves are preferred for transplantation by virtue of their lowthrombogenicity and immunogenicity, superior hemodynamic performance, and extended durability, onlyabout 2,000 per year are implanted due to limited donated heart supply. An acellular porcine heart… More

We will develop a strong, safe, easy-to-use, biocompatible, and degradable bioadhesive for surgicalrequiring tissue sealing and closure. This bioadhesive will have the potential to streamline commonwell as provide new technology in areas such as organ hemostasis. The following specific aims will… More

Although the autogenous saphenous vein is the vessel typically utilized in arterial bypass procedurarise in which it is not possible to use this vein, demanding an alternative method. The investigatofeasibility study in canine subjects to determine whether an immunologically modified xenogeneic… More

Autologous patellar tendon grafts are the current gold standard for replacement of irreparable anteligaments. Allogeneic tissue grafts are the only accepted alternative to autologous grafts and theysupply. We will develop a non-immunogenic bovine fascia lata as a graft material for anterior… More