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REPOPULATION OF XENOGRAFT HEART VALVES WITH FIBROBLASTS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
16715
Program Year/Program:
1991 / SBIR
Agency Tracking Number:
16715
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
CRYOLIFE, INC.
1655 ROBERTS BLVD, NW KENNESAW, GA 30144
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1991
Title: REPOPULATION OF XENOGRAFT HEART VALVES WITH FIBROBLASTS
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

DURING THE LAST 20 YEARS, ALLOGRAFT HEART VALVE TRANSPLANTATION IN THE UNITED STATES HAS INCREASED FROM ABOUT 50 TO 2,000 PER ANNUM. BECAUSE OF THIS INCREASED DEMAND, PARTICULARLY FOR PEDIATRIC CASES, UTILIZATION OF THESE CRYOPRESERVED HEART VALVES IS NOW LIMITED BY THE SUPPLY OF DONATED HUMAN HEARTS. THE OBJECTIVE IS TO CONVERT XENOGRAFT HEART VALVES INTO ALLOGRAFTS IN AN ATTEMPT TO RESOLVE THIS SUPPLY PROBLEM. LOW-DOSE-IRRADIATE, XENOGRAFT HEART VALVES WILL BE TREATED TO INDUCE GROWTH FACTOR-IRRADIATED, ALLOGENIC FIBROBLAST INGROWTH INTO THE XENOGRAFT HEART VALVE LEAFLETS. PORCINE HEART VALVES AND BOVINE FIBROBLASTS WILL BE USED. ONCE THE OPTIMUM SOURCE AND METHOD FOR FIBROBLAST INGROWTH HAS BEEN DETERMINED, ALLOGENIC FIBROBLAST-REPOPULATED XENOGRAFT HEART VALVE LEAFLETS WILL BE IMPLANTED IN CALVES. THE TRANSPLANT STUDY WILL BE SHORT TERM (3 MONTHS) AND WILL CONCENTRATE ON DETERMINING THE BEHAVIOR OF THE FIBROBLASTS IN THE HEART VALVE LEAFLETS. THE CELL BIOLOGY EXPERIMENTS WILL BE PERFORMED AT CRYOLIFE, INC., AND THE TRANSPLANTATION STUDIES AT COLORADO STATE UNIVERSITY.

Principal Investigator:

Brockbank, Kelvin G
Principal Investigator
4049521660

Business Contact:

1 r43 hl46607-01
Small Business Information at Submission:

Cryolife, Inc
2211 New Market Parkway Marietta, GA 30067

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No