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Food Toxicity Detection Using C. elegans

Award Information

Agency:
Department of Defense
Branch:
Office of the Secretary of Defense
Award ID:
96894
Program Year/Program:
2010 / SBIR
Agency Tracking Number:
O093-H24-3231
Solicitation Year:
N/A
Solicitation Topic Code:
OSD 09-H24
Solicitation Number:
N/A
Small Business Information
Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY 14850-
View profile »
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: Yes
 
Phase 1
Fiscal Year: 2010
Title: Food Toxicity Detection Using C. elegans
Agency / Branch: DOD / OSD
Contract: W81XWH-10-C-0213
Award Amount: $100,000.00
 

Abstract:

Current toxicity testing of foodstuffs involves mass spectrometry analysis which requires a >24 h turnaround time in deployed military operations. This length of time is dangerous for personnel. Rapid identification of toxic industrial chemicals (TICs) in food using a sensor that is biologically-based and easy to use eliminates that danger and would provide exactly what is needed for toxicity evaluation of food. In this Phase I, Agave BioSystems proposes to develop a rapid and accurate biosensor using mutant C. elegans to evaluate toxicity in food. This biosensor will use the nematode C. elegans as the model system and measure Green fluorescent protein (GFP) that has been linked to inducible promoters of genes responsive to specific stressors. Extended shelf life will be possible because the dauer stage within the lifecycle of C. elegans leaves the worm in stasis for extended periods of time until growth is resumed with improved conditions. By measuring the GFP response in a mixed population of mutant C. elegans, the outcome should be an accurate and sensitive assessment of chemical toxicity in food.

Principal Investigator:

Kathie Berghorn
Staff Scientist
6072720002
kberghorn@agavebio.com

Business Contact:

Noe Salazar
President
5126566200
nsalazar@agavebio.com
Small Business Information at Submission:

Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY 14850

EIN/Tax ID: 161551819
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No