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Point-of-Care Diagnostic for Acute Q Fever using LAMP

Award Information

Agency:
Department of Defense
Branch:
N/A
Award ID:
92028
Program Year/Program:
2010 / SBIR
Agency Tracking Number:
A2-4000
Solicitation Year:
2008
Solicitation Topic Code:
A08-178
Solicitation Number:
2008.3
Small Business Information
Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2010
Title: Point-of-Care Diagnostic for Acute Q Fever using LAMP
Agency: DOD
Contract: W81XWH-09-C-0036
Award Amount: $730,000.00
 

Abstract:

Q fever, caused by the bacterium Coxiella burnetii, presents with acute symptoms indistinguishable from many other blood infections. Chronic infection, more frequently developing in immunocompromised individuals, presents a high mortality rate (up to 60% of chronic cases) and often requires open-heart surgery to repair substantial valve damage. Q fever can be airborne or tick-borne and is a significant detriment in deployment conditions. It is important to diagnose Q-fever during its acute phase to direct appropriate treatment and identify personnel requiring follow-up monitoring for chronic disease. While serology tests have been commercialized for Q fever detection, it is necessary to test both IgG and IgM against two types of C. burnetii antigens to differentiate between acute and chronic disease stages. Additionally, a high false positive rate occurs for these assays, and the antibody response is difficult to detect early in infection. To eliminate these shortcomings, Agave BioSystems proposed to integrate a loop-mediated isothermal amplification (LAMP) reaction built into a point-of-care field diagnostic device. To date, we have been highly successful with the implementation of a breadboard device for real time readings and expect to continue the development of a hand-held, fully-enclosed device, capable of providing early detection of acute phase Q-Fever.

Principal Investigator:

Janet Huie
Staff Scientist
(607) 272-0002
jhuie@agavebio.com

Business Contact:

Noe Salazar
President
(512) 656-6200
nsalazar@agavebio.com
Small Business Information at Submission:

Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY -

EIN/Tax ID: 161551819
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: Yes