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IMPROVED SYNTHESIS OF RADIORECEPTOR LIGANDS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
13703
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
13703
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Custom Synthesis Inc
3122 W Clay St Seay Bldg #207 Richmond, VA 23230
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1990
Title: IMPROVED SYNTHESIS OF RADIORECEPTOR LIGANDS
Agency: HHS
Contract: N/A
Award Amount: $49,000.00
 

Abstract:

THIS RESEARCH WILL EXPAND UPON PRELIMINARY STUDIES THAT DEMONSTRATED THE FEASIBILITY OF A SOLID-PHASE, FLOW-THROUGH DEVICE TO CARRY OUT CATALYTIC HYDROGEN TRANSFER REACTIONS. THESE STUDIES USED PALLADIUM-COATED GLASS FIBER FILTERS AS WELL AS SILICA/POLYVINYLCHLORIDE MEMBRANE. PHASE I RESEARCH WILL EVALUATE OTHER SUPPORTS, FOR EXAMPLE, CONTROLLED PORE GLASS AND SILICA/POLYETHYLENE MEMBRANES, AS MATRICES FOR THIS PROCEDURE. IN ADDITION, A THIOL SCAVENGER SUPPORT WILL BE PREPARED AND TESTED AS A DEVICE TOREDUCE OR ELIMINATE CATALYST POISONING. STUDIES WILL ALSO BE CARRIED OUT TO DETERMINE IF NICKEL DEPOSITED ON THESE MATRICES WILL SUPPORT CATALYSIS IN THE SAME WAY AS THE PALLADIUM-COATED SUPPORTS. THE UTILITY OF ISOPROPANOL AS A HYDROGEN DONOR IN CATALYTIC HYDROGEN TRANSFER REACTIONS WILLALSO BE STUDIED. BASED ON THE ABOVE, A DEVICE AND PROTOCOL WILL BE DEVELOPED THAT CAN CATALYZE DEHALOHYDROGENATION REACTIONS WITH THE ULTIMATE GOAL BEING DEVELOPMENT OF A FACILE METHOD FOR THE PREPARATION OF ISOTOPICALLY LABELED LIGANDS FOR USE IN A VARIETY OF BIOMEDICAL/BIOCHEMICAL APPLICATIONS.

Principal Investigator:

Alan R Day
8043555405

Business Contact:

Small Business Information at Submission:

Custom Synthesis Inc
3122 W Clay St Seay Bldg #207 Richmond, VA 23230

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No