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A Point-of-Care Field Assay for Dengue Viruses

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
97702
Program Year/Program:
2010 / SBIR
Agency Tracking Number:
A093-155-1329
Solicitation Year:
N/A
Solicitation Topic Code:
Army 09-155
Solicitation Number:
N/A
Small Business Information
Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY 14850-
View profile »
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: Yes
 
Phase 1
Fiscal Year: 2010
Title: A Point-of-Care Field Assay for Dengue Viruses
Agency / Branch: DOD / ARMY
Contract: W81XWH-10-C-0038
Award Amount: $70,000.00
 

Abstract:

Dengue viruses are transmitted by mosquito vectors throughout tropical and subtropical regions of Asia, Africa, and Central and South America. Four serotypes circulate, DEN-1 through -4, and immunity to one type does not preclude illness from another type and can exacerbate subsequent disease with another type. While dengue fever can be a mild infection, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) cause death at a high rate and are associated with multiple serotypes worldwide. Dengue fever symptoms, especially at the early acute stage, can resemble infection with other disease agents, such as malaria and rickettsial diseases, with different treatment regimens. Loop-mediated isothermal amplification (LAMP) is a recently developed technique with similar or better detection sensitivity and specificity compared to PCR assays, but allows a single temperature incubation and simple readout more suitable to field devices. LAMP also offers the potential of detection in less pure samples, such as blood, facilitating quick field sample preparation. Therefore, Agave BioSystems proposes to develop a real-time reverse-transcriptase loop-mediated isothermal amplification (real-time RT-LAMP) diagnostic for detection of Dengue viruses in human serum.

Principal Investigator:

Janet Huie
Staff Scientist
6072720002
jhuie@agavebio.com

Business Contact:

Noe Salazar
President
5126566200
esmidt@irlabs.com
Small Business Information at Submission:

Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY 14850

EIN/Tax ID: 161551819
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No