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SOFTWARE FOR GROUP-SEQUENTIAL CANCER CLINICAL TRIALS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7922
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
7922
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
CYTEL SOFTWARE CORPORATION
CYTEL SOFTWARE CORPORATION 675 MASSACHUSETTS AVE CAMBRIDGE, MA 02139
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: Yes
 
Phase 2
Fiscal Year: 1990
Title: SOFTWARE FOR GROUP-SEQUENTIAL CANCER CLINICAL TRIALS
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

LARGE MULTI-INSTITUTIONAL TWO-ARM RANDOMIZED CLINICAL TRIALS, IN WHICH THE PRIMARY ENDPOINT IS THE TIME UNTIL A SPECIFIC EVENT (SUCH AS DEATH FROM CANCER) OCCURS, ARE GENERALLY CONDUCTED AS FIXED SAMPLE STUDIES. THERE ARE, HOWEVER, ETHICAL AND ECONOMIC PRESSURES TO MONITOR THE ACCUMULATING DATA AND TO TERMINATE SUCH STUDIES EARLIER THAN WAS ORIGINALLY PLANNED, WHEN STRONG EVIDENCE EMERGES THAT ONE TREATMENT IS CLEARLY SUPERIOR TO THE OTHER, OR THATBOTH TREATMENTS ARE EQUALLY INEFFECTIVE. ALTHOUGH THEORY AND METHODS FOR SUCH SEQUENTIAL MONITORING HAVE BEEN AVAILABLE SINCE 1940, THEY WERE NOT APPLICABLE TO TYPICAL CHRONIC DISEASE TRIALS, SINCE THE MATHEMATICAL RESULTS WERE ONLY VALID IF THE RESULTS OF THE EXPERIMENT COULD BE OBSERVED INSTANTLY AND THE DATA WERE MONITORED CONTINUOUSLY. SINCE 1975, MAJOR TECHNICAL ADVANCES HAVE APPEARED IN THE STATISTICAL LITERATURE THAT MAKE IT MATHEMATICALLY FEASIBLE TO DESIGN SEQUENTIAL MEDICAL TRIALS EVEN WHEN THE RESPONSE IS DELAYED, AND THE DATA ARE MONITORED IN GROUPS. INCREASING PRESSURE IS THEREFORE BEING EXERTED ON STATISTICAL UNITS TO APPLY THESE NEW TECHNIQUES TO ON-GOING AND FUTURE STUDIES. A MAJOR OBSTACLE IS THE TOTAL ABSENCE OF A FLEXIBLE AND FRIENDLY SOFTWARE PACKAGE TO GUIDE STATISTICIANS INTO SELECTING THE RIGHT SEQUENTIAL DESIGN FOR THEIR NEEDS. WE INTEND TO DEVELOP SUCH A MICROCOMPUTER BASED SOFTWARE PACKAGE WITH THE HELP OF CONSULTANTS WHO HAVE THEMSELVES MADE MAJOR CONTRIBUTIONS TO THE NEW STATISTICAL METHODOLOGY FOR SEQUENTIAL CLINICAL TRIALS.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Cytel Software Corp.
137 Erie St Cambridge, MA 02139

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No