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PHENYLHYDRAZONES WITH ANTIESTROGEN ACTIVITIES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
11147
Program Year/Program:
1991 / SBIR
Agency Tracking Number:
11147
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
DEKK-TEC, INC.
725 TOPAZ STREET NEW ORLEANS, LA 70124-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1991
Title: PHENYLHYDRAZONES WITH ANTIESTROGEN ACTIVITIES
Agency: HHS
Contract: N/A
Award Amount: $440,486.00
 

Abstract:

SUBSTITUTED BENZOPHENONE PHENYLHYDRAZONES HAVE BEEN SYNTHESIZED AND HAVE DEMONSTRATED GOOD ANTIESTROGEN ACTIVITIES WITH LOW TO ABSENT INTRINSIC ESTROGENICITY (IN ANIMMATURE RAT UTERI ASSAY). 4,4(,)-DIHYDROXYBENZOPHENONE-2, 4-DINITROPHENYLHYDRAZONE (A-007) HAS DEMONSTRATED A 38-PERCENT CR WITH AN OVERALL 25- TO 50-PERCENT REDUCTION INTUMOR VOLUME OF DMBA-INDUCED RAT BREAST TUMORS. THIS IS IN CONTRAST TO A 125-PERCENT INCREASE IN TUMOR VOLUME PRODUCED BY TAMOXIFEN AND AN 850-PERCENT INCREASE SEEN IN THE CONTROLANIMALS. STUDIES USING THE COLONY-FORMING ASSAY (CFA) DOCUMENTED A-007'S ABILITY TO INHIBIT THE COLONIZATION OF HUMAN BREAST AND OVARIAN CANCERS AND NORMAL HUMAN ENDOMETRIAL CELLS. THESPECIFIC OBJECTIVES OF THIS PHASE I STUDY WILL BE TO INITIATE A-007 RAT AND MOUSE ACUTE/CHRONIC TOXICITY STUDIES AND TO DOCUMENT BONE MARROW TOXICITY OF A-007 USING THE GRANULOCYTE-MACROPHAGE COLONY-FORMING CELL ASSAY. DEKK-TEC, INC., WILL CONTINUE TO SYNTHESIZE AND SCREEN SUBSTITUTED HYDRAZONES FOR ANTIESTROGEN AND ANTICANCER PROPERTIES IN IMMATURE RATS AND IN ZR-75-1 HUMAN BREAST CANCER CELLS IN THE CFA.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Dekk-tec Inc.
3839 Ulloa St #100 New Orleans, LA 70199

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No