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ARYL HYDRAZONES WITH ANTICANCER ACTIVITIES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
19087
Program Year/Program:
1992 / SBIR
Agency Tracking Number:
19087
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
DEKK-TEC, INC.
725 TOPAZ STREET NEW ORLEANS, LA 70124-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1992
Title: ARYL HYDRAZONES WITH ANTICANCER ACTIVITIES
Agency: HHS
Contract: N/A
Award Amount: $49,998.00
 

Abstract:

SUBSTITUTED BENZOPHENONE PHENYLHYDRAZONES HAVE BEEN IDENTIFIED THAT POSSESS ANTIESTROGEN ACTIVITIES WITH ABSENT ESTROGENICITY. 4, 4'-DIHYDROXYBENZOPHENONE-2, 4-DINITROPHENYLHDRAZONE (A-007) HAS DEMONSTRATED ANTIESTROGENIC ACTIVITIES AT LOW CONCENTRATIONS AND CYTOTOXIC ACTIVITIES AT HIGHER CONCENTRATIONS IN ESTROGEN INDEPENDENT BREAST CANCERS. A-007 IS PRESENTLY BEING PREPARED FOR CLINICAL STUDIES. THE 2, 2'-DIHYDROXY ISOMER OF A-007 HAS RECENTLY BEEN PREPARED, A-701, AND IS TWICE AS CYTOTOXIC AS THE FORMER. IT IS NOT ANTIESTROGENIC AND X-RAY CRYSTALLOGRAPY STUDIES REVEAL TWO SETS OF INTRAMOLECULAR HYDROGEN BONDING. A-071 THUS, CONTAINS MORE POTENTIAL COPLANARITY THAN DOES A-007, WHICH MAY BE INFLUENCING BIOLOGICAL ACTIVITIES. THE SPECIFIC OBJECTIVES OF THIS PHASE I STUDY WILL BE TO MODIFY A-007'S HYDRAZONE AND BENZOPHENONE MOIETIES USING X-RAY CRYSTALLOGRAPHY MODELLING AND CHEMICAL REACTIVITY TO INTRODUCE PLANARITY AND FUNCTIONAL GROUPS THAT MAY POTENTIATE OR MODIFY BIOLOGICAL ACTIVITIES. ALL SYNTHESIZED HYDRAZONES WILL BE ASSAYED IN VITRO IN HUMAN/MOUSE CELL LINES, THE GRANULOCYTE/MACROPHAGE COLONY FORMING CELL ASSAY (GM-CFC), IN THE IMMATURE UTERINE RAT MODEL AND IN RAT/MOUSE ACUTE/CHRONIC TOXICITY STUDIES.

Principal Investigator:

Lee R Morgan
5044885415

Business Contact:

Small Business Information at Submission:

Dekk Tec Inc
3839 Ulloa Street New Orleans, LA 70119

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No