USA flag logo/image

An Official Website of the United States Government

A-007: IMMUNE MODULATION OF HPV - CERVICAL CANCER

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
53806
Program Year/Program:
2001 / SBIR
Agency Tracking Number:
1R43CA089772-01
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
DEKK-TEC, INC.
725 TOPAZ STREET NEW ORLEANS, LA 70124-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2001
Title: A-007: IMMUNE MODULATION OF HPV - CERVICAL CANCER
Agency: HHS
Contract: N/A
Award Amount: $191,517.00
 

Abstract:

DESCRIPTION: (Applicant's Description) 4,4'-Dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) has recently completed a Phase I clinical trial in advanced cancer with minimal toxicity and objective responses noted. Preliminary observations suggest that A-007 is able to stimulate lymphocyte mobilization when applied topically to normal skin, as well as, to metastatic cutaneous lesions. The specific objectives of this Phase I study will be to document A-007's ability to stimulate lymphocyte migration/activation in cancers associated with immunodeficiency related infections. A-007's functional groups will be modified to maximize pharmacophore activities. All new hydrazones, as well as, A-007 will be assayed in vitro/in vivo for lymphocyte stimulation properties. These studies will be expanded for use as a stimulant of local cervical immunity in a simian immunodeficiency virus (SIV) monkey model and as local treatment for young females with HPV-associated cervical cancers. PROPOSED COMMERCIAL APPLICATION: 4,4'-Dihydroxybenzophenone-2, 4-dinitrophenylhydrazone (A-007) is showing lymphocyte stimulation and anticancer activities in clinical trials. A new agent with anticancer/immune modulation activity in HPV associated cervical cancer would have wide use as a single agent or in combinations therapy.

Principal Investigator:

Lee R. Morgan

Business Contact:


5044885417
LRM1579@AOL.COM
Small Business Information at Submission:

DEKK-TEC, INC.
4200 CANAL ST, STE A NEW ORLEANS, LA 70119

EIN/Tax ID: 720976996
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No