Chronic progressive heart failure will be produced in sheep by administration of specific myocardiotoxic drugs. in phase i, project feasibility will be determined by administering allylamine, doxorubricin, or cobalt chloride in varying doses to healthy sheep, then following changes which occur with… More

Retrovenous diastolic myocardial perfusion (rvdp) with oxygenated blood via the coronary sinus and coronary veins has been shown experimentally to provide 45% of the normal coronary blood flow. rvdp therapy could significantly alter the morbidity of patients with coronary artery disease and acute… More

Multimonitors for ecg, temperature, heart sounds, and breath sounds will be fabricated on endotracheal tubes and bench tested. the capability of monitoring multiple physiologic parameters from a single anatomic site (the trachea) is cost efficient in terms of current practice and will provide better… More

This study is designed to develop and evaluate a method of replacing a hollow viscus with a prosthesis that allows primary mucosal healing and incorporation of the prosthetic into the healing process. healing of a full thickness isolated bowel segment to 2 types of a hollow viscus prosthesis will be… More