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Construction of Vascular Structures with Human Tropoelastin

Award Information

Agency:
National Science Foundation
Branch:
N/A
Award ID:
98830
Program Year/Program:
2010 / SBIR
Agency Tracking Number:
0945065
Solicitation Year:
N/A
Solicitation Topic Code:
BMS
Solicitation Number:
N/A
Small Business Information
Protein Genomics
PMB 13419 2675 W HWY 89A Sedona, AZ 86336-5240
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2010
Title: Construction of Vascular Structures with Human Tropoelastin
Agency: NSF
Contract: 0945065
Award Amount: $199,213.00
 

Abstract:

This Small Business Innovation Research (SBIR) Phase I project proposes to make new blood vessels by using a synthesized human protein as a guide for growing human cells into tissues. The guide will be molded into a tubular shape. The protein, a water soluble form of human elastin can be produced by fermentation and will be purified, mixed with a catalyst and cast into tubular shaped molds made of glass or plastic. After the protein has set up in the tubular mold, it will be removed, tested for its strength and ability to stretch, and mixed with human epithelial cells in tissue culture media. The cells will be allowed to grow on and within the solidified protein to form a combination of a strong, elastic vessel surrounded by layers of human cells. The broader impacts of this research are the availability of new and better performing blood vessel material for dialysis patients. Dialysis patients experience problems with damage to their blood vessels during the dialysis procedure. These complications currently cost a total of $1.5 billion extra. Reducing the costs, pain and complications by using a new vascular material represents a large benefit to patients and physicians.

Principal Investigator:

Burt Ensley
PhD
9282034127
burt@burtensley.com

Business Contact:

Burt Ensley
PhD
9282034127
burt@burtensley.com
Small Business Information at Submission:

Protein Genomics
PMB 13419 2675 W HWY 89A Sedona, AZ 86336

EIN/Tax ID: 263338945
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No