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Novel Methods for Rapid Detection of Infection Agents and the Severity of…

Award Information

Department of Defense
Defense Advanced Research Projects Agency
Award ID:
Program Year/Program:
2008 / STTR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
3535 Breakwater Avenue Hayward, CA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2008
Title: Novel Methods for Rapid Detection of Infection Agents and the Severity of Cellular Damage
Agency / Branch: DOD / DARPA
Contract: W31P4Q-08-C-0417
Award Amount: $99,000.00


The development of early detection methods to aid in the identification of virulent infectious pathogens is of strategic importance so that exposed warfighters and other individuals can be treated early or appropriately quarantined. We are currently developing a nucleic acid-based assay that can selectively and sensitively detect and quantify the RNA or DNA specific to a broad range of pathogens in the blood of infected individuals. In addition, the assay might also be useful for detection of radiation exposure and for following the severity of tissue damage during an infection. The assay has the following advantages: 1) it is comparable to real-time PCR in terms of sensitivity and accuracy in dsDNA and superior for RNA pathogens; 2) it has a standard curve for precise quantification, which is better than cycle number used in real-time PCR; 3) it can be expanded to multiplex bead systems for simultaneous detection of a large number of pathogens; 4) it does not have the complexity of real-time PCR methodology that requires training and experience; and 5) the result is read-out by chemiluminescent substrate using a portable and durable luminometer, which can be handheld and low cost.

Principal Investigator:

Aiguo Zhang
Principal Investigator

Business Contact:

Yunqing Ma
Chief of Staff
Small Business Information at Submission:

6519 Dumbarton Circle Fremont, CA 94555

EIN/Tax ID: 023806012
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
ORPA (RC Box 270140)
518 Hylan Building
Rochester, NY 14627
Contact: Donna Beyea
Contact Phone: (585) 275-8036
RI Type: Nonprofit college or university