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CAD-CAM TECHNOLOGY FOR DIABETIC FOOTWEAR

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
54428
Program Year/Program:
2001 / SBIR
Agency Tracking Number:
1R43DK059074-01
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
DIAPEDIA, LLC
270 WALKER DR., STE 207E STATE COLLEGE, PA 16801-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2001
Title: CAD-CAM TECHNOLOGY FOR DIABETIC FOOTWEAR
Agency: HHS
Contract: N/A
Award Amount: $199,143.00
 

Abstract:

DESCRIPTION (Adapted from the Investigator's Abstract): Gastrointestinal (GI) ulceration and hemorrhage is a major health problem in our country representing billions of dollars in health care costs and lost revenues from work place. Despite sophisticated therapeutic agents, the disturbing problem of high recurrence rate of bleeding, even after complete healing, remains. About one third of the patients treated with traditional ulcer therapy have recurrent hemorrhage. There is a need for developing new drugs that can arrest hemorrhage. In our pilot work we have shown that the organic extract of Chinese herbal preparation, Yunnan baiyao, has favorable influence on severe intestinal syndromes produced by indomethacin, and is also effective in promoting the healing and preventing GI ulcers in rat models. We have also shown that the extract contains at least two potent factors that induce aggregation of human platelets. We propose in this SBIR application to optimize methods for extraction as well as establish the molecular identity and mode of action of active principles that exhibit platelet aggregatory activities. We plan to carry out biological assays specific for anti-ulcerative and anti-hemorrhagic properties. The Phase I study will lay the foundation essential for the full development of the active factors into anti-hemorrhagic drug in Phase II studies. PROPOSED COMMERCIAL APPLICATION: The market for an effective and safe therapeutic agent to treat several types of hemorrhagic disorder notably bleeding from esophageal varices, gastric and duodenal ulcers will be enormous.

Principal Investigator:

Joseph L. Loomis

Business Contact:


8142388522
MAIL@DIAPEDIA.COM
Small Business Information at Submission:

DIAPEDIA, LLC
1352 DEERFIELD DR STATE COLLEGE, PA 16803

EIN/Tax ID: 251858279
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No