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PDGF EXPRESSION IN PROLIFERATIVE RETINOPATHIES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
8009
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
8009
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Digene
Univ Of Maryland Bldg 334 College Park, MD 20742
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1988
Title: PDGF EXPRESSION IN PROLIFERATIVE RETINOPATHIES
Agency: HHS
Contract: N/A
Award Amount: $46,000.00
 

Abstract:

PLATELET-DERIVED GROWTH FACTOR (PDGF) MAY STIMULATE PROLIFERATION OF CELLS WHICH LEAD TO THE DEVELOPMENT OF VARIOUS PROLIFERATIVE RETINOPATHIES. FURTHERMORE, PDGF MAY BE ESPECIALLY IMPORTANT IN REGULATING THE REGROWTH OF MEMBRANES FOLLOWING INITIAL THERAPEUTIC SURGERY. THUS, IT HAS BEEN HYPOTHESIZED THAT MEASUREMENT OF PDGF LEVELS IN THEPROLIFERATIVE MEMBRANE REMOVED DURING SURGERY COULD: (1) PREDICT THE LIKELIHOOD OF RECURRENCE; AND (2) ALLOW SPECIAL INTERVENTION TO PREVENT RECURRENCE IN HIGH-RISK SITUATIONS. WE PROPOSE USING A DNA HYBRIDIZATION METHOD THAT HAS BEEN ESTABLISHED TO BE SUITABLE FOR THE RAPID ANALYSIS OF PARAFFIN-EMBEDDED HISTORICAL SPECIMENS. THIS METHOD HAS BEEN USED SUCCESSFULLY TO DETECT MRNAS OF SEVERAL RETINAL PROTEINS (OPSIN, S-ANTIGEN). THE GOALS OF PHASE I ARE: 1) TO DEMONSTRATE THE FEASIBILITY OF USING A SIMPLE AND SENSITIVE NON-RADIOACTIVE PROCEDURE TOIDENTIFY AND LOCALIZE THE SITES OF PRODUCTION OF PDGF; AND (2) DEMONSTRATE THE FEASIBILITY OF GATHERING DATA ON THE CORRELATION OF PDGF EXPRESSION WITH SEVERAL PROLIFERATIVE RETINAL DISORDERS. UPON MEETING THESE OBJECTIVES, A PHASE II STUDY WOULD INCLUDE A LARGER SCALE RETROSPECTIVE ANALYSISON THE PATHOPHYSIOLOGY OF THESE DISORDERS.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Digene
Bldg 334 University Of Maryland College Park, MD 20742

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No