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Company Information:

Name: Divergence, Inc.
Address: 893 North Warson Road
Saint Louis, MO
Located in HUBZone: No
Woman-Owned: No
Minority-Owned: No
URL: N/A
Phone: (314) 812-8024

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $2,151,550.00 18
SBIR Phase II $3,417,866.00 7

Award List:

TARGET VALIDATION METHODS FOR NEMATODE CONTROL AGENTS

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Andrew P. Kloek
Award Amount: $99,958.00
Abstract:
DESCRIPTION (provided by applicant): Parasitic nematodes infect over one half of the world's population, causing significant morbidity and mortality. Currently available methods of control have only partially alleviated this problem. A long term objective of the… More

Nematode Intestinal Proteins as Anthelmintic Targets

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: NSF
Principal Investigator: Michelle Hresko
Award Amount: $93,016.00
Abstract:
This Small Business Innovation Research Phase I project proposes to identify potential targets for the development of therapeutic agents to treat infections by parasitic nematodes. Nematode infections represent a serious heath concern for both humans and domesticated animals and, as such, represent… More

TARGET VALIDATION METHODS FOR NEMATODE CONTROL AGENTS

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Andrew P. Kloek
Award Amount: $0.00
Abstract:
Infections by roundworm parasites, called nematodes, result in human mortality and morbidity, especially in subtropical and tropical regions of Africa, Asia, and the Americas. The World Health Organization estimates 2.9 billion people are infected. There are 595 known nematode parasites of… More

TARGET VALIDATION METHODS FOR NEMATODE CONTROL AGENTS

Award Year / Program / Phase: 2002 / SBIR / Phase II
Agency: HHS
Principal Investigator: Andrew P. Kloek
Award Amount: $637,462.00
Abstract:
Infections by roundworm parasites, called nematodes, result in human mortality and morbidity, especially in subtropical and tropical regions of Africa, Asia, and the Americas. The World Health Organization estimates 2.9 billion people are infected. There are 595 known nematode parasites of… More

SBIR Phase I: Transgenic Strategy for Nematode Control

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: NSF
Principal Investigator: Rodolfo Zentella
Award Amount: $100,000.00
Abstract:
This Small Business Innovation Research (SBIR) Phase I project proposes to develop transgenic crop plants exhibiting increased resistance to nematode infection and damage. Present strategies for dealing with nematode infections involve chemicals that are both toxic and environmentally hazardous. A… More

SBIR Phase II: Nematode Intestinal Proteins as Anthelmintic Targets

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency: NSF
Principal Investigator: Michelle Hresko, PI
Award Amount: $500,000.00
Abstract:
This Small Business Innovation Research Phase II project proposes to develop transgenic roots that are resistant to nematode infection, through expression of small proteins, protein domains or peptides which when ingested by the nematode interfere with the function of essential proteins of the… More

Anthelmintic Compounds Targeting Methyltransferases

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: USDA
Principal Investigator: Michelle C. Hresko
Award Amount: $80,000.00
Abstract:
The long-term goal of this project is to develop and commercialize anthelmintic drugs to treat nematode infections of animals. Control of parasitic nematode infections in livestock and companion animals is currently dependent on chemical classes discovered more than two decades ago. The economic… More

A New Safer Class of Agricultural Nematicides Targeting a Specific Gene

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: USDA
Principal Investigator: Barry Shortt
Award Amount: $80,000.00
Abstract:
Plant parasitic nematodes are among the most important pests of crops in the United States. The USDA's Committee on National Needs and Priorities in Nematology estimated the value of plant damage by nematodes in the U.S. at $7-9 billion annually. Chemical control of nematodes has proven to be… More

SBIR Phase I: Identification of Nematicidal Peptides by Phage Display

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: NSF
Principal Investigator: Michelle Hresko, PI
Award Amount: $100,000.00
Abstract:
This Small Business Innovation Research (SBIR) Phase I project proposes to develop transgenic plants that are resistant to plant-parasitic nematode infection and damage. The approach is to use phage display technology to identify small peptides that bind to and interfere with the function of… More

Functional Genomic Approach to Macrofilaricide Discovery

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: James P. Mccarter
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): River blindness and lymphatic filariasis, two disease caused by filarial nematodes, are among the most important tropical diseases. Blackfly transmission of the nematode Onchocercus volvulus leads to river blindness (onchocerciasis), while mosquito-transmitted… More

A Safer Class of Agricultural Nematicides Based on Natural Fatty Acid Products

Award Year / Program / Phase: 2006 / SBIR / Phase II
Agency: USDA
Principal Investigator: Barry Shortt
Award Amount: $296,000.00
Abstract:
Plant parasitic nematodes are among the most important crop pathogens in the United States, causing an estimated $7-9 billion in lost yield annually. Traditional nematicides, including organophosphates, are under severe regulatory pressure because of toxological and environmental concerns. The… More

SBIR Phase I: Intracellular delivery of nematicidal proteins

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: NSF
Principal Investigator: Michelle C. Hresko, Dr
Award Amount: $100,000.00
Abstract:
This Small Business Innovation Research (SBIR) Phase I research project will develop a method to use cell-penetrating peptides (CPPs) to carry bioactive proteins across cell membranes in plant parasitic nematodes. Multiple CPPs will be developed which cross nematode cell membranes when attached to a… More

Use of a Plant Universal Molecular Recognition Library for Root Knot Nematode Resistance

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: USDA
Principal Investigator: Jennifer T. Jones, Senior Scientist
Award Amount: $80,000.00
Abstract:
Plant parasitic nematodes annually cause damage in excess of $8 billion in the U.S. and $78 billion worldwide. The goal of this research is to generate crops, such as cotton and tomato, with broad-spectrum, season-long resistance to root knot nematode.

SBIR Phase I: Scaffold Technology for Effector Molecules (STEM): A Transgenic Platform for Agriculture

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: NSF
Principal Investigator: Jennifer Jones, Dr
Award Amount: $100,000.00
Abstract:
This Small Business Innovation Research (SBIR) Phase I research project will develop a novel enabling technology for transgenic solutions to agricultural problems. Scaffold Technology for Effector Molecules (STEM) will allow the generation of high-affinity bioactive proteins capable of selectively… More

SBIR Phase I: Control of Lesion Nematodes by Transgenic RNA Interference

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: NSF
Principal Investigator: James P. McCarter, DPhil
Award Amount: $100,000.00
Abstract:
This Small Business Innovation Reserach (SBIR) Phase I research will generate transgenic crops with resistance to plant parasitic nematodes with a focus on the lesion nematode (Pratylenchus). Plant parasitic nematodes annually cause damage of $8 billion in the U.S. and are among the most difficult… More

Functional Genomic Approach to Macrofilaricide Discovery

Award Year / Program / Phase: 2007 / SBIR / Phase II
Agency: HHS
Principal Investigator: James P. Mccarter
Award Amount: $734,404.00
Abstract:
DESCRIPTION (provided by applicant): Parasitic filarial nematodes causing lymphatic filariasis and river blindness (onchocerciasis), infect over 140 million people with up to one billion at risk in at least 80 countries and territories. Lymphatic filariasi s (caused by Wuchereria and Brugia species)… More

Control of Root Knot Nematodes by Transgenic RNA Interference

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: USDA
Principal Investigator: Bingli Gao, Director of Transgenic Discovery
Award Amount: $80,000.00
Abstract:
Non Technical Summary: The goal of this research is to generate transgenic crops with broad-spectrum, season-long resistance to root knot nematode (RKN, Meloidogyne sp.). Plant parasitic nematodes, of which RKN is the most significant, annually cause damage of $8 billion in the U.S. and $78 billion… More

Novel and Effective Agrochemicals Derived From the Analysis of Molecular Fields

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: USDA
Principal Investigator: Michael J. Crawford, Senior Discovery Scientist
Award Amount: $80,000.00
Abstract:
Non Technical Summary: Current estimates indicate that one-third of worldwide agricultural output is lost to pests and diseases such as pathogenic fungi. Despite advancements in chemical control, the rapid onset of resistance to pesticides often limits their utility. In addition, the vast majority… More

Novel Macrofilaricidal Compounds: Target Identification and Chemical Optimizatio

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): Parasitic infect over 140 million people, with up to one billion at risk in 80 countries. Lymphatic filariasis creates an enormous health and economic burden within affected areas and is the second leading cause of long -term disability. In 2000, international… More

Novel and Effective Antifungal Compounds Derived from Molecular Field Analysis

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $108,576.00
Abstract:
DESCRIPTION (provided by applicant): Invasive fungal infections are an increasingly common and serious cause of illness and death in the U.S. and worldwide. Infection by Candida albicans has increased tenfold to become more frequent than diseases caused by E. coli and Pseudomonas, and it has become… More

Use of a Plant Universal Molecular Recognition Library for Root Knot Nematode Resistance

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency: USDA
Principal Investigator: Bingli Gao, Director of Transgenic Discovery
Award Amount: $350,000.00
Abstract:
The goal of this research is to generate crops, such as tomato, corn and carrot, with broad spectrum, season long resistance to root knot nematode. Plant parasitic nematodes, of which root knot is the most significant, annually cause damage in excess of $8 billion in the U.S. and $80 billion… More

SBIR Phase II: Control of Lesion Nematodes by Transgenic RNA Interference

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: NSF
Principal Investigator: James P. McCarter, DPhil
Award Amount: $500,000.00
Abstract:
This Small Business Innovation Research (SBIR) Phase II project will use RNA interference (RNAi) to limit damage to corn from the plant parasite lesion nematode by silencing genes in the parasite. Phase I demonstrated in culture that expression of specific double-stranded RNAs (dsRNAs) from lesion… More

SBIR Phase I: Novel Advanced Nematicides with Improved Efficacy and Safety

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: NSF
Principal Investigator: Urszula Slomczynska, MEE
Award Amount: $150,000.00
Abstract:
This SBIR Phase I project will develop novel nematicides using proprietary chemical design and screening methods. The project will first design, prioritize, and synthesize a set of entirely novel molecules. The project will then evaluate compounds for activity in multiple biological assays with… More

Facile Detection of Soil-Transmitted Helminth Infections

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael J. Crawford
Award Amount: $600,000.00
Abstract:
DESCRIPTION (provided by applicant): The goal of this project is to develop a rapid and accurate immunodiagnostic test for detection of soil- transmitted helminths (STHs) that can be used without laboratory infrastructure. Human STH infect ions from whipworm (Trichuris), roundworm… More

Novel Agrochemical Leads Derived from Molecular Fields

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency: USDA
Principal Investigator: Michael J. Crawford, Director
Award Amount: $400,000.00
Abstract:
An estimated one-third of worldwide crop production is lost to pathogens including fungi. Despite advances in chemical control, the onset of resistance limits the utility of current fungicides. In addition, most pesticide research projects are terminated because of unattractive attributes of the… More