DESCRIPTION (provided by applicant): Parasitic nematodes infect over one half of the world's population, causing significant morbidity and mortality. Currently available methods of control have only partially alleviated this problem. A long term objective of the… More

This Small Business Innovation Research Phase I project proposes to identify potential targets for the development of therapeutic agents to treat infections by parasitic nematodes. Nematode infections represent a serious heath concern for both humans and domesticated animals and, as such, represent… More

Infections by roundworm parasites, called nematodes, result in human mortality and morbidity, especially in subtropical and tropical regions of Africa, Asia, and the Americas. The World Health Organization estimates 2.9 billion people are infected. There are 595 known nematode parasites of… More

Infections by roundworm parasites, called nematodes, result in human mortality and morbidity, especially in subtropical and tropical regions of Africa, Asia, and the Americas. The World Health Organization estimates 2.9 billion people are infected. There are 595 known nematode parasites of… More

This Small Business Innovation Research (SBIR) Phase I project proposes to develop transgenic crop plants exhibiting increased resistance to nematode infection and damage. Present strategies for dealing with nematode infections involve chemicals that are both toxic and environmentally hazardous. A… More

This Small Business Innovation Research Phase II project proposes to develop transgenic roots that are resistant to nematode infection, through expression of small proteins, protein domains or peptides which when ingested by the nematode interfere with the function of essential proteins of the… More

The long-term goal of this project is to develop and commercialize anthelmintic drugs to treat nematode infections of animals. Control of parasitic nematode infections in livestock and companion animals is currently dependent on chemical classes discovered more than two decades ago. The economic… More

Plant parasitic nematodes are among the most important pests of crops in the United States. The USDA's Committee on National Needs and Priorities in Nematology estimated the value of plant damage by nematodes in the U.S. at $7-9 billion annually. Chemical control of nematodes has proven to be… More

This Small Business Innovation Research (SBIR) Phase I project proposes to develop transgenic plants that are resistant to plant-parasitic nematode infection and damage. The approach is to use phage display technology to identify small peptides that bind to and interfere with the function of… More

DESCRIPTION (provided by applicant): River blindness and lymphatic filariasis, two disease caused by filarial nematodes, are among the most important tropical diseases. Blackfly transmission of the nematode Onchocercus volvulus leads to river blindness (onchocerciasis), while mosquito-transmitted… More

Plant parasitic nematodes are among the most important crop pathogens in the United States, causing an estimated $7-9 billion in lost yield annually. Traditional nematicides, including organophosphates, are under severe regulatory pressure because of toxological and environmental concerns. The… More

This Small Business Innovation Research (SBIR) Phase I research project will develop a method to use cell-penetrating peptides (CPPs) to carry bioactive proteins across cell membranes in plant parasitic nematodes. Multiple CPPs will be developed which cross nematode cell membranes when attached to a… More

Plant parasitic nematodes annually cause damage in excess of $8 billion in the U.S. and $78 billion worldwide. The goal of this research is to generate crops, such as cotton and tomato, with broad-spectrum, season-long resistance to root knot nematode.

This Small Business Innovation Research (SBIR) Phase I research project will develop a novel enabling technology for transgenic solutions to agricultural problems. Scaffold Technology for Effector Molecules (STEM) will allow the generation of high-affinity bioactive proteins capable of selectively… More

This Small Business Innovation Reserach (SBIR) Phase I research will generate transgenic crops with resistance to plant parasitic nematodes with a focus on the lesion nematode (Pratylenchus). Plant parasitic nematodes annually cause damage of $8 billion in the U.S. and are among the most difficult… More

DESCRIPTION (provided by applicant): Parasitic filarial nematodes causing lymphatic filariasis and river blindness (onchocerciasis), infect over 140 million people with up to one billion at risk in at least 80 countries and territories. Lymphatic filariasi s (caused by Wuchereria and Brugia species)… More

Non Technical Summary: The goal of this research is to generate transgenic crops with broad-spectrum, season-long resistance to root knot nematode (RKN, Meloidogyne sp.). Plant parasitic nematodes, of which RKN is the most significant, annually cause damage of $8 billion in the U.S. and $78 billion… More

Non Technical Summary: Current estimates indicate that one-third of worldwide agricultural output is lost to pests and diseases such as pathogenic fungi. Despite advancements in chemical control, the rapid onset of resistance to pesticides often limits their utility. In addition, the vast majority… More

DESCRIPTION (provided by applicant): Parasitic infect over 140 million people, with up to one billion at risk in 80 countries. Lymphatic filariasis creates an enormous health and economic burden within affected areas and is the second leading cause of long -term disability. In 2000, international… More

DESCRIPTION (provided by applicant): Invasive fungal infections are an increasingly common and serious cause of illness and death in the U.S. and worldwide. Infection by Candida albicans has increased tenfold to become more frequent than diseases caused by E. coli and Pseudomonas, and it has become… More

The goal of this research is to generate crops, such as tomato, corn and carrot, with broad spectrum, season long resistance to root knot nematode. Plant parasitic nematodes, of which root knot is the most significant, annually cause damage in excess of $8 billion in the U.S. and $80 billion… More

This Small Business Innovation Research (SBIR) Phase II project will use RNA interference (RNAi) to limit damage to corn from the plant parasite lesion nematode by silencing genes in the parasite. Phase I demonstrated in culture that expression of specific double-stranded RNAs (dsRNAs) from lesion… More

This SBIR Phase I project will develop novel nematicides using proprietary chemical design and screening methods. The project will first design, prioritize, and synthesize a set of entirely novel molecules. The project will then evaluate compounds for activity in multiple biological assays with… More

DESCRIPTION (provided by applicant): The goal of this project is to develop a rapid and accurate immunodiagnostic test for detection of soil- transmitted helminths (STHs) that can be used without laboratory infrastructure. Human STH infect ions from whipworm (Trichuris), roundworm… More

An estimated one-third of worldwide crop production is lost to pathogens including fungi. Despite advances in chemical control, the onset of resistance limits the utility of current fungicides. In addition, most pesticide research projects are terminated because of unattractive attributes of the… More