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Epi-fluorescence array microscope

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
81211
Program Year/Program:
2006 / SBIR
Agency Tracking Number:
EB004187
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
DMETRIX, INC.
9030 South Rita Rd Ste 389 TUCSON, AZ -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2006
Title: Epi-fluorescence array microscope
Agency: HHS
Contract: 1R43EB004187-01A2
Award Amount: $107,904.00
 

Abstract:

DESCRIPTION (provided by applicant): DMetrix is developing a line of innovative array-microscope slide scanner instruments to generate virtual slides. Our core technology is an array of miniature objectives, each measuring less than 2 mm in diameter and 7 mm in length, slightly staggered in the array, to produce a single, seamless sweep of a microscope slide. The array microscope concept relies on imaging in parallel in order to significantly reduce the time necessary to acquire digital, high-resolution microscope-slide images. We propose here to develop an epi-fluorescence configuration of the array-microscope concept. The proposed epi-fluorescence array-microscope system will include 100 miniature microscope objectives designed and optimized for fluorescence imaging by DMetrix. This array microscope will be based on a novel "many-to-one" optics configuration that allows efficient and simultaneous illumination of the 100 miniature objectives' fields of view. The long-term goal is to create a high-throughput, highly automated fluorescence microscope. The array-microscope virtual-slide scanner will allow digitization of fluorescently labeled specimens at rates at least 10 times faster than conventional single-optical-axis optical systems. Applications of such an epi-fluorescence virtual slide scanner are to be found in molecular pathology, pharmaceutical research, case archiving, and telepathology. The high scanning speed of the proposed instrument will enable either a high throughput measured in slides/day or the acquisition of multi-layer ("z- stack") and/or multi-spectral image sets in minutes per slide.

Principal Investigator:

Chen Liang
5207229510
LIANG@DMETRIX.COM

Business Contact:

Michael Descour
5207229510
DESCOUR@DMETRIX.COM
Small Business Information at Submission:

DMETRIX, INC.
DMETRIX, INC. 1141 W. GRANT RD. TUCSON, AZ 85705

EIN/Tax ID: 861036587
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No