The mission of DNA Software Inc. is to enable the field of genomics by writing enterprise grade simulation software that incorporates state-of- the-art knowledge of the thermodynamics and kinetics of nucleic acid folding and hybridization. To accomplish this goal, we are developing core software… More

DESCRIPTION (provided by applicant): The goal of this proposal is to develop new software for designing polymerase chain reaction (PCR) DNA amplifications in various formats based upon a rigorous scientific and computational approach. DNA Software Inc. has created the "oligonucleotide modeling… More

DESCRIPTION (provided by applicant): The human genome encodes approximately 30,000 genes, and alternative splicing results in approximately 100,000 different RNAs in the cell. Genomic discoveries for disease susceptibility require thermodynamic knowledge in RNA-DNA interactions to create optimal… More

DESCRIPTION (provided by applicant): The human genome encodes approximately 30,000 genes, and alternative splicing results in approximately 100,000 different RNAs in the cell. Genomic discoveries for disease susceptibility require thermodynamic knowledge in RNA-DNA interactions to create optimal… More

DESCRIPTION (provided by applicant): The mission of DNA Software Inc. is to enable the field of genomics by writing enterprise grade simulation software that incorporates state-of-the-art knowledge of the thermodynamics and kinetics of nucleic acid folding and hybridization. To accomplish this goal,… More

DESCRIPTION (provided by applicant): Oligonucleotide probes and primers are a crucial component of most diagnostic assays used for detection and quantification of genomic material. For a genomic assay to be effective, it must be both highly sensitive and simultaneously produce a low false positive… More

DESCRIPTION (provided by applicant): Oligonucleotide probes and primers are a crucial component of most diagnostic assays used for detection and quantification of genomic material. For a genomic assay to be effective, it must be both highly sensitive and s imultaneously produce a low false positive… More

Not avaiable.

DESCRIPTION (provided by applicant): This research proposal has the goal of measuring the rate of reaction of DNA strands with DNA or RNA to form a duplex structure, building a mathematical model for determining the rate constant of that reaction, and inco rporating that model into existing software… More

DESCRIPTION (provided by applicant): The exponential growth of sequence databases in the genomics era was promoted by the desire to understand fundamental macromolecular structural mechanisms, and how these structures interact with oligonucleotides, protei ns and metabolites in a cell. However, a… More

DESCRIPTION (provided by applicant): A greatly expanded thermodynamic database for modified oligonucleotides will be developed in this project and incorporated into existing design software. This Fast Track SBIR proposal focuses on determining thermodynamic parameters for modifications that are… More

DESCRIPTION (provided by applicant): This research proposal has the goal of measuring the rate of reaction of DNA strands with DNA or RNA to form a duplex structure, building a mathematical model for determining the rate constant of that reaction, and inco rporating that model into existing software… More

DESCRIPTION (provided by applicant): A greatly expanded thermodynamic database for modified oligonucleotides will be developed in this project and incorporated into existing design software. This Fast Track SBIR proposal focuses on determining thermodynam ic parameters for modifications that are… More

DESCRIPTION (provided by applicant): The exponential growth of sequence databases in the genomics era was promoted by the desire to understand fundamental macromolecular structural mechanisms, and how these structures interact with oligonucleotides, protei ns and metabolites in a cell. However, a… More

DESCRIPTION (provided by applicant): The discovery of new and interesting RNA sequences from genome sequencing projects, and the urgency to unravel their functions, has led to a dramatic push for novel structural determination techniques. Current experimen tal methods for three dimensional structure… More

DESCRIPTION (provided by applicant): In this grant proposal An Automated Antisense Design and Simulation Platform , a comprehensive molecular diagnostics software tool that is specific to the design and simulation of antisense oligonucleotide analog probes will be developed. The application of… More

DESCRIPTION (provided by applicant): The discovery of new and interesting RNA sequences from genome sequencing projects, and the urgency to unravel their functions, has led to a dramatic push for novel structural determination techniques. Current experimental methods for three dimensional structure… More

DESCRIPTION (provided by applicant): In this grant proposal An Automated Antisense Design and Simulation Platform , a comprehensive molecular diagnostics software tool that is specific to the design and simulation of antisense oligonucleotide analog probes will be developed. The application of… More