NON-TECHNICAL SUMMARY: Short Tandem Repeat (STR) loci consist of short, repetitive sequence elements ranging from 2 to 5 base pairs (bp) in length distributed throughout mammalian genomes (microsatellites). STR genotypes can be determined from polymerase chain reaction (PCR) products of less 500 bp… More

In order to assure accurate detection of exposure to biological warfare agents or any environmental agents, it is necessary to exclude a variety of common conditions that may confound proper diagnosis. Many groups, including ours , have found that biological warfare agents can stimulate… More

To assure accurate detection of exposure to biological warfare agents or any environmental agents, it is necessary to exclude a variety of common conditions that may confound proper diagnosis. Many groups, including ours, have found that biological warfare agents can stimulate inflammatory… More

Transmissible spongiform encephalopathies (TSEs), or prion diseases, are caused by a unique transmissible agent hypothesized to be a misfolded form (PrPD) of a normal host protein (PrPC). We will use chronic wasting disease (CWD) as a model prion agent because there is an urgent need for increased… More

Transmissible spongiform encephalopathies (TSE's), or prion diseases, are caused by a unique transmissible agent hypothesized to be a misfolded form (PrPD) of a normal host protein (PrPC). We will use chronic wasting disease (CWD) as a model prion agent because of growing concern about this agent,… More