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Diagnostic Microarray Test Based on Comparative Studies of Gene Expression in…

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
68035
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
A032-3974
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
DNA SOLUTIONS, INC.
840 Research Parkway Suite 551 Oklahoma City, OK 73104
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: Diagnostic Microarray Test Based on Comparative Studies of Gene Expression in Humans with Common Inflammatory and Infectious Diseases
Agency / Branch: DOD / ARMY
Contract: W81XWH-04-C-0039
Award Amount: $69,136.00
 

Abstract:

In order to assure accurate detection of exposure to biological warfare agents or any environmental agents, it is necessary to exclude a variety of common conditions that may confound proper diagnosis. Many groups, including ours , have found that biological warfare agents can stimulate inflammatory systems, the same systems found stimulated in common inflammatory disease such as rheumatoid arthritis, inflammatory bowel disease or ankylosing spondylitis. In order to create an accurate diagnostic tool, it is therefore necessary to define the changes in gene expression that are characteristic of these common inflammatory diseases in clinically accessible tissue (such as peripheral blood) and compare them with the genetic expression level changes characteristic of exposure to biological warfare agents. The database of genes that make this distinction most effectively will be used in the creation of a practical diagnostic test. The addition of the work proposed herein to our existing projects will result in complete expression databases for rheumatoid arthritis, inflammatory bowel disease, hepatitis C and ankylosing spondylitis. This will allow for the creation of a straightforward test reflecting only the gene expression changes indicative of exposure to particular biological warfare agents or existing inflammatory conditions

Principal Investigator:

Tom Kupiec
President/CEO
4052711114
tkupiec@arlok.com

Business Contact:

Gary Cook
Director of Fianance
4052711144
gcook@arlok.com
Small Business Information at Submission:

DNA SOLUTIONS, INC.
840 Research Parkway, Suite 546 Oklahoma City, OK 73104

EIN/Tax ID: 731585135
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No