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Data Driven Sequence Assembly

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
25116
Program Year/Program:
1994 / SBIR
Agency Tracking Number:
25116
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
DNASTAR, INC.
1228 S PARK ST MADISON, WI 53715
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1994
Title: Data Driven Sequence Assembly
Agency: HHS
Contract: 1 R43 GM51680-1,
Award Amount: $75,000.00
 

Abstract:

This grant will improve the software for DNA sequencing by integrating the components of basecalling, sequence assembly and post-assembly analysis into an integrated software system. To test theperformance of the software configurations, data for known regions of E. coli will be resequenced fromthe original clones using a LI-Cor sequencing instrument. The data will be basecalled by neural net basedpattern recognition and assembled with a variety of multiple alignment methods. Algorithmic solutionswill be compared and evaluated relative to the goal of achieving an accurate final sequence with theminimum of editing by a human expert. Alleviating the need for sequence editing will present theopportunity for significant cost savings in genome projects and other research involving DNA sequencing.

Principal Investigator:

Schuyler Baldwin
6082587420

Business Contact:

Small Business Information at Submission:

Dnastar, Inc.
1228 S Park Street Madison, WI 53715

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No