The proposed work is intended to reduce the cost of magnetic resonance diagnostic imaging (mri) by developing suitable, low-noise, low-cost class ab pulse amplifiers with substantially lower initial costs and operating costs. novel transformer geometries and materials are proposed for reducing… More

A new approach to high efficiency heat exchanger design shows that theoretical limits to specific conductance are about 100,000 times greater than is currently achieved in most state-of-the-art compact exchangers, but practical considerations reduce this factor to perhaps 100. prototype micro-tube… More

Several candidate circuits are proposed for microwave op amps, based on preliminary demonstrations of concept feasibility using discrete silicon devices. a hybrid approach employing a silicon ic input stage with a gaas mesfet output stage is shown to be the most promising in achieving the design… More

50069-98-I Development of a 1W, 10 K Reverse Brayton Cycle Crycooler--Doty Scientific, Inc., 700 Clemson Road, Columbia, SC 29229-4339; (803) 788-6497 Dr. F. David Doty, Principal Investigator Mr. George Entzminger, Business Official DOE Grant No. DE-FG02-98ER82565 Amount: $75,000 High… More

DESCRIPTION (Provided by Applicant): Improvements in signal to noise ratio (SNR) and ease of use of magnetic resonance imaging (MRI) rf coils are needed to improve image quality and patient throughput. The goal of this Phase I project is to develop a novel rf coil… More

DESCRIPTION (Applicant's abstract verbatim): The object of this Phase I proposal is to demonstrate feasibility of a gradient coil suitable for human head Magnetic Resonance Imaging (MRI) microscopy at fields from 1 to 8 T with substantially higher performance than is… More

DESCRIPTION: (provided by applicant) Available methods for molecular structure determination, based primarily on x-ray crystallography and Nuclear Magnetic Resonance (NMR) solution methods, have had very limited success on the insoluble helical transmembrane proteins that… More

"Preliminary analysis and simulations show a novel, recuperated, open Brayton cycle gas turbine should achieve system specific mass (including the generator and power conditioning) below 5 kg/kWE and efficiency of 35-50% over the range of 1-1000 kW withextremely low thermal and acoustic signatures… More

DESCRIPTION (provided by applicant): Recently, Magic Angle Spinning (MAS) has been combined with high-field high-resolution Nuclear Magnetic Resonance (HR-NMR) to extend the technique to inhomogeneous systems, such as human and animal tissues. The 1 H HR-MAS spectrum of malignant breast cancer… More

DESCRIPTION (provided by applicant):Improvements in signal to noise ratio (SNR) and ease of use of magnetic resonance imaging (MRI) RF coils are needed to improve image quality and patient throughput. The goal of this Phase II project is to continue the development of novel rf coil topologies and rf… More

DESCRIPTION (provided by applicant):Improvements in signal to noise ratio (SNR) and ease of use of magnetic resonance imaging (MRI) RF coils are needed to improve image quality and patient throughput. The goal of this Phase II project is to continue the development of novel rf coil topologies and rf… More

DESCRIPTION (provided by applicant): Available methods for molecular structure determination, based primarily on x-ray crystallography and Nuclear Magnetic Resonance (NMR) solution methods have limitations. While the x-ray methods are several orders of magnitude faster, NMR techniques are required… More

DESCRIPTION (provided by applicant): The goal of this Phase II proposal is to complete the development and demonstration of a novel gradient coil suitable for human head Magnetic Resonance Imaging (MRI) at fields from 1 to 8 T with substantially higher performance than is currently available.… More

DESCRIPTION (provided by applicant): The goal of this Phase II proposal is to complete the development and demonstration of a novel gradient coil suitable for human head Magnetic Resonance Imaging (MRI) at fields from 1 to 8 T with substantially higher performance than is currently available.… More

DESCRIPTION (provided by applicant): For over three decades, High-Resolution (HR) Nuclear Magnetic Resonance (NMR) has been a leading analytical technique for structure and function elucidation of molecules of all types, large and small, in homogeneous systems. More recently, Magic Angle Spinning… More

DESCRIPTION (provided by applicant): Improved signal to noise ratio (SNR) and ease of use for magnetic resonance imaging (MRI) apparatus are needed to improve image quality and throughput in high-field MRI in research using small animal models. While linear-polarization (LP) mouse imaging has been… More

DESCRIPTION (provided by applicant): Available methods for biological molecular structure determination, based primarily on x-ray crystallography and Nuclear Magnetic Resonance (NMR) solution methods, have limitations. While the x-ray methods are several orders of magnitude faster, NMR techniques… More

DESCRIPTION (provided by applicant): Preliminary data demonstrate that a radically different approach to MRI gradient coil design permits substantial advantages in all respects; especially in short, high-field magnets - higher gradient strength, reduced acoustic noise, and reduced nerve stimulation.… More

DESCRIPTION (provided by applicant): The goal of this project is to develop a series of ultra-high-performance, double-tuned, cryogenic, cost-effective, MRI rf coil platforms, especially for improved MR spectroscopy (MRS) in pre-clinical studies in small animals at high-fields. Substantial gains… More

DESCRIPTION (provided by applicant): Available methods for molecular structure determination, based primarily on x-ray crystallography and Nuclear Magnetic Resonance (NMR) solution methods, have had limited success on the insoluble proteins that are critic al to bio- logical function. Various recent… More

DESCRIPTION (provided by applicant): Compared to current practice with whole-body-gradient coils, an advanced head gradient coil promises over twice the gradient strength (for higher resolution) and at least three times higher slew rates (for faster imagi ng sequences), with an order of magnitude… More

DESCRIPTION (provided by applicant): For over three decades, High-Resolution (HR) Nuclear Magnetic Resonance (NMR) has been a leading analytical technique for structure and function elucidation of molecules of all types, large and small, in homogeneous sys tems. More recently, Magic Angle Spinning… More

DESCRIPTION (provided by applicant): Available methods for molecular structure determination, based primarily on x-ray crystallography and Nuclear Magnetic Resonance (NMR) solution methods, have had limited success on the insoluble proteins that are critic al to biological function. Various recent… More

This SBIR Phase I project will demonstrate that a novel thermodynamic cycle could enable a 50% improvement in conversion efficiency from geothermal and concentrated solar sources when the two are synergistically combined. The broader/commercial impact of the proposed project could be as much as a… More

DESCRIPTION (provided by applicant): Magic Angle Spinning (MAS) is utilized by thousands of Nuclear Magnetic Resonance (NMR) researchers in fields such as macromolecule structure determination, membrane proteins, catalysis, and organo-metallo-complexes. For over three decades, High-Resolution (HR)… More