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Advanced, Convenient, Small-Animal MRI for 11-19 T

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
70780
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
RR019155
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
DOTY SCIENTIFIC, INC.
700 CLEMSON RD COLUMBIA, SC -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: Advanced, Convenient, Small-Animal MRI for 11-19 T
Agency: HHS
Contract: 1R43RR019155-01
Award Amount: $198,757.00
 

Abstract:

DESCRIPTION (provided by applicant): Improved signal to noise ratio (SNR) and ease of use for magnetic resonance imaging (MRI) apparatus are needed to improve image quality and throughput in high-field MRI in research using small animal models. While linear-polarization (LP) mouse imaging has been demonstrated in a 500 MHz (11.7 T) vertical-bore magnet, available apparatus for vertical-bore magnets above 300 MHz is poorly suited for use with the physiologically monitored mouse or juvenile rat. Hence, most researchers prefer to use horizontal bore magnets, which are not widely available above 200 MHz and unavailable above 500 MHz. Prior work has demonstrated the unique contributions possible from our proprietary simulation software and patented coil technologies for both advanced gradients and circular-polarization (CP) MRI RF coils. We denote our rf coils "litz.cages", as they embody both paralleled conductor elements with insulated crossovers similar to that in our prior "ritz coil" technology and capacitively segmented phase shifts with four-point drive to achieve highly stable circular polarization. The litzcage has demonstrated order-of-magnitude improvement in tunability (ability to tune and match efficiently over a wide range of sample loading conditions). The proposed 24 mm 750 MHz RF coil is expected to provide a factor of 6 increases in SNR compared to the CP 200 MHz horizontal case, or a factor of 2.5 gains in SNR compared to the LP 500 MHz case. Our prior work has also established some essential requirements for rapid and convenient handling of physiologically monitored small animals in horizontal-bore magnets. The Phase I effort will also develop and construct a novel high-performance, water-cooled gradient coil of 47 mm bore compatible with 60 G/cm pulsed gradients at 19 T for use with the mouse RF coil and animal handling system. Field-testing of the Phase 1 750 MHz apparatus will begin early in Phase II at the Advanced MR Imaging and Spectroscopy Facility, McKnight Brain Institute, University of Florida, Gainesville, FL. The primary objectives are to achieve substantial improvements in resolution, convenience, and cost effectiveness for small-animal imaging in existing high-field vertical-bore magnets.

Principal Investigator:

F. D. Doty
8037886497
david@dotynmr.com

Business Contact:

David Mccree
8037886497
DAVE@DOTYNMR.COM
Small Business Information at Submission:

DOTY SCIENTIFIC, INC.
DOTY SCIENTIFIC, INC. 700 CLEMSON RD COLUMBIA, SC 29229

EIN/Tax ID: 570736944
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No