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Colorimetric Sensors for Chemical and Biological Warfare Agents

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
77875
Program Year/Program:
2006 / STTR
Agency Tracking Number:
A064-024-0120
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ANDalyze Inc.
2109 S. Oak St. Suite 102 Champaign, IL 61820-7460
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2006
Title: Colorimetric Sensors for Chemical and Biological Warfare Agents
Agency / Branch: DOD / ARMY
Contract: W9132T-06-C-0037
Award Amount: $99,997.00
 

Abstract:

We aim to construct litmus paper-like colorimetric sensors for detection and quantification of chemical and biological agents in water by performing combinatorial selection of DNA aptamers for cyanobacteria toxins such as microcystins and saxitoxins. Aptamers are single stranded DNA that can bind target molecules with high affinity and specificity. Such DNA aptamers are biocompatible, biodegradable, and highly stable even at elevated temperatures and dry conditions, especially when conjugated with nanoparticles. Cyanobacteria toxins are the most encountered toxins in water sources. After obtaining toxin-specific aptamers, DNA-functionalized gold nanoparticles will be used to obtain rapid, autonomous, cost-effective and easily interpretable sensors for soldiers in the field. The sensors will be made into a test strip format that can be easily used by soldiers or other users without a chemistry background. Importantly, the same technology will be applicable to detect a broad range of chemical and biological agents without an extensive support system. In the Phase I research, the feasibility of using the proposed approach will be demonstrated and prototype test kits will be constructed and characterized in Phase II.

Principal Investigator:

Lu Yi
2173332619
yi-lu@uiuc.edu

Business Contact:

Lu Geng
Senior Scientist
2173779806
lugengca@gmail.com
Small Business Information at Submission:

DZYMETECH, INC.
2001 South First St. Suite 201 Champaign, IL 61820

EIN/Tax ID: 202863203
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
UNIV. OF ILLINOIS AT U-C
1901 S. First St. , Ste. A
Champaign, IL 61820
Contact: Kathy Young
Contact Phone: (217) 333-6323
RI Type: Nonprofit college or university