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SEVERAL ANALYTICAL METHODOLOGIES ARE AVAILABLE TO MONITOR AGRICULTURAL…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4906
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4906
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
East Acres Biologicals
236 Blackmer Road Po Box 822 Southbridge, MA 01550
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: SEVERAL ANALYTICAL METHODOLOGIES ARE AVAILABLE TO MONITOR AGRICULTURAL CHEMICALS SUCH AS PARATHION IN ENVIRONMENTAL SAMPLES AND EXTRACTS FROM FOOD PRODUCTS.
Agency: HHS
Contract: N/A
Award Amount: $49,000.00
 

Abstract:

SEVERAL ANALYTICAL METHODOLOGIES ARE AVAILABLE TO MONITOR AGRICULTURAL CHEMICALS SUCH AS PARATHION IN ENVIRONMENTAL SAMPLES AND EXTRACTS FROM FOOD PRODUCTS. IN ADDITION, METHODS ARE AVAILABLE TO MONITOR SOME PESTICIDES IN SAMPLES OF BIOLOGICAL FLUIDS. HOWEVER, THESE METHODS ARE GENERALLY BASED ON THE USE OF SOPHISTICATED INSTRUMENTATION AND THE EXPENSE AND TIME INVOLVED MAKE THEM GENERALLY UNSUITABLE FORBROAD-SCALE EPIDEMIOLOGICAL STUDIES. IN ADDITION, THE AVAILABLE TECHNOLOGY IS NOT GENERALLY ADAPTABLE TO NON- LABORATORY ENVIRONMENTS. IN CONTRAST, IMMUNOCHEMICAL TECHNIQUES PROVIDE RELIABLE DETECTION OF SPECIFIC ANTIGENS, ARE COST-EFFECTIVE, AND CAN BE USED BY RELATIVELY UNSKILLED INDIVIDUALS IN NONLABORATORY SETTINGS. MOREOVER, IMMUNO- CHEMICAL REAGENTS CAN BE USED TO DETECT AND QUANTITATE IN SITU VIA IMMUNOCHEMICAL STAINING OF RESIDUE ACCUMULATION IN TISSUES AT THE CELLULAR OR SUBCELLULAR LEVEL. FINALLY, IMMUNOCHEMICAL METHODS CAN BE DESIGNED TO DETECT SPECIFIC ANTIGENS OR WHOLE FAMILIES OF RELATED ANTIGENS. IN THIS REGARD, IMMUNOCHEMICAL METHODS ARE UNIQUELY SUITED FOR BROAD-SCALE SCREENING STUDIES. THEREFORE, IT IS PROPOSED THAT SEVERAL APPROACHES BE EXPLORED TO DEVELOP ASSAYS FOR THE IMMUNOCHEMICAL DETECTION OF PESTICIDE RESIDUE USING PARATHION AS A TEST MODEL. AN INNOVATIVE APPROACH TO THIS PROBLEM WILL INCLUDE THE USE OF LIPOSOMES AND ADJUVANTS TO PREPARE THE DESIRED IMMUNOCHEMICAL REAGENTS. THESE NEW METHODS WILL COMPLEMENT PROTEIN CONJUGATION AS A TOOL FOR ANTIBODY PRODUCTION AGAINST LOW MOLECULAR WEIGHT PESTICIDE HAPTENES.

Principal Investigator:

Kenneth s pickren
PRINCIPAL INVESTIGATOR
6177659580

Business Contact:

Small Business Information at Submission:

East Acres Biologicals
236 Blackmer Road Po Box 822 Southbridge, MA 01550

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No