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Company Information:

Name: ECHELON BIOSCIENCES, INC.
Address: 675 ARAPEEN DRIVE, SUITE 302
SALT LAKE CITY, UT 84108-
Located in HUBZone: No
Woman-Owned: No
Minority-Owned: No
URL: N/A
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $3,979,780.00 24
SBIR Phase II $2,934,868.00 5
STTR Phase I $469,299.00 4
STTR Phase II $818,456.00 3

Award List:

ISOPRENOID COMPOUNDS FOR BIOLOGICAL STUDIES

Award Year / Program / Phase: 1998 / STTR / Phase I
Agency: HHS
Research Institution: University of Utah
Principal Investigator: Poulter
Award Amount: $99,950.00
RI Contact: N/A

SOLUBLE AND ANTIGENIC PHOSPHOINOSITIDE PHOSPHATES

Award Year / Program / Phase: 1998 / STTR / Phase I
Agency: HHS
Research Institution: University of Utah
Principal Investigator: Prestwich
Award Amount: $91,800.00
RI Contact: N/A

N/A

Award Year / Program / Phase: 1999 / STTR / Phase II
Agency: HHS
Research Institution: University of Utah
Principal Investigator: Prestwich
Award Amount: $274,028.00
RI Contact: N/A

PHOSPHOINOSITIDE 3-KINASE ASSAYS IN CANCER DIAGNOSIS

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael J. Mostert
Award Amount: $104,385.00
Abstract:
Not Available A high efficiency and precision control pneumatic/mechanical actuator which converts chemical to mechanical energy will extend human performance and provide advantages in reducing system weight and bulk. Quoin will analyze the concept of an actuator based on a central air compressor… More

IMMOBILIZED PHOSPHOINOSITIDES FOR LIPID KINASE ASSAYS

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gene A. Stark
Award Amount: $106,958.00
Abstract:
Not Available There have been number of new technologies have been developed over the past decade to produce metallic and ceramic nanopowders, the market for which is growing rapidiv. However, much needed user-friendly characterization techniques for this new class of materials have not been… More

N/A

Award Year / Program / Phase: 2000 / STTR / Phase I
Agency: HHS
Research Institution: University of Utah
Principal Investigator: Poulter
Award Amount: $0.00
RI Contact: N/A

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jodi Dufnerbeattie
Award Amount: $105,038.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Veronica H. Kang
Award Amount: $104,515.00

CELL PERMEANT PHOSPHOINOSITIDES

Award Year / Program / Phase: 2001 / SBIR / Phase II
Agency: HHS
Principal Investigator: Paul O. Neilsen
Award Amount: $496,798.00

CELL PERMEANT PHOSPHOINOSITIDES

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Paul O. Neilsen
Award Amount: $0.00

Protein Overlays for Phosphoinositide Detection

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Colin G. Ferguson
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): Phosphoinositides (PIPns), e.g., phosphatidylinositol 4,5-bisphosphate (PI 4,5) P2) are key signaling molecules in cellular communication. Specific PIPns recruit target signaling proteins and intracellular adapter proteins to inner… More

LIPID MICROARRAYS

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Li Feng
Award Amount: $200,000.00
Abstract:
Phosphoinositides (PIP/nS), phospholipids (PLs), and sphingolipids (SLs) recruit signaling proteins and effectors to initiate signal transduction in response to internal and external signals.. Cellular processes such as endocytosis, protein sorting, cell proliferation, apoptosis, and cytoskeletal… More

PHOSPHOINOSITIDE 3-KINASE ASSAYS IN CANCER DIAGNOSIS

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Beth E. Drees
Award Amount: $0.00
Abstract:
Phosphoinositides are key lipid second messengers in cellular signaling. No approved diagnostics evaluate lipids as markers for cancer, but analysis of lipids in addition to protein and DNA may enhance overall accuracy of diagnosis and simultaneously suggest a molecular target for treatment. The… More

ANTIBIOTIC SCREEN FOR ISOPRENOID PATHWAY IN B.ANTHRACIS

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Mark J. Brown
Award Amount: $98,560.00
Abstract:
DESCRIPTION (provided by applicant): Isoprenoid compounds form a large ubiquitous class of natural products that fulfill a wide variety of essential cellular functions in al living organisms. In eukaryotes, isoprenoid compounds are synthesized by a mevalonate (MVA) dependent pathway. However, in… More

LIPID PHOSPHATASE ASSAYS IN DISEASE AND DRUG DISCOVERY

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Beth E. Drees
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): Phosphoinositide phosphates (PlPns) are important second messengers in signaling pathways controlling cellular proliferation, survival, morphology, and motility. Disruption of these pathways is common to many disease states, including diabetes, cardiovascular… More

PHOSPHOINOSITIDE 3-KINASE ASSAYS IN CANCER DIAGNOSIS

Award Year / Program / Phase: 2002 / SBIR / Phase II
Agency: HHS
Principal Investigator: Beth E. Drees
Award Amount: $717,262.00
Abstract:
Phosphoinositides are key lipid second messengers in cellular signaling. No approved diagnostics evaluate lipids as markers for cancer, but analysis of lipids in addition to protein and DNA may enhance overall accuracy of diagnosis and simultaneously suggest a molecular target for treatment. The… More

LIPOSOME OVERLAYS FOR PROTEIN-LIGAND SELECTIVITY

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Colin G. Ferguson
Award Amount: $100,000.00
Abstract:
Phosphoinositides (PIPns), e.g., phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), are key signaling molecules in cellular communication. Specific PIPns recruit target signaling proteins and intracellular adapter proteins to inner membrane sites to activate protein kinases and thereby initiate… More

HIGH-THROUGHPUT FLUORESCENT PROTEIN KINASE ASSAYS

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Michael J. Mostert
Award Amount: $100,110.00
Abstract:
DESCRIPTION (provided by applicant): Protein kinases catalyze the phosphorylation of serine (Ser), threonine (Thr), and tyrosine (Tyr) residues in peptides and proteins, and comprise the largest superfamily of enzymes in eukaryotes with an estimated 500 genes in the human genome. Because most… More

Liposome Overlays For Protein-Ligand Selectivity

Award Year / Program / Phase: 2003 / SBIR / Phase II
Agency: HHS
Principal Investigator: Colin G. Ferguson
Award Amount: $684,906.00
Abstract:
DESCRIPTION (provided by applicant): Phosphoinositides (PIPnS) are integral signaling molecules for cellular communication. By recruiting specific proteins to the inner membrane, signal cascades are then initiated leading to downstream effects such as protein sorting, tumorigenesis, regulation of… More

Discovery of Antagonists of Phosphoinositide Signaling

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Leena Chakravarty
Award Amount: $500,000.00
Abstract:
DESCRIPTION (provided by applicant): Phosphoinositides are key lipid second messengers in many cellular signaling processes. In particular, the activity of phosphatidylinositol 3-kinase (PI 3-K), and the synthesis of its lipid products, is important in pathways mediating cell proliferation,… More

Screen for Isoprenoid Production in M. tuberculosis

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Mark J. Brown
Award Amount: $109,120.00
Abstract:
DESCRIPTION (provided by applicant): Isoprenoid compounds form a large ubiquitous class of natural products that fulfill a wide variety of essential cellular functions in all living organisms. In eukaryotes, isoprenoid compounds are synthesized by a mevalonate (MVA) dependent pathway. However, in… More

Fluorogenic Assays for Phospholipid Detection

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Li Feng
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): Phospholipids (PL) including phosphoinositides (PIPn) are crucial structural and signaling molecules for proper inter- and intra-cellular communication in an organism. The disruption of lipid homeostasis is associated with numerous human pathologies. High… More

Hybrid Phospholipid-Phosphoinositides

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Paul O. Neilsen
Award Amount: $100,152.00
Abstract:
DESCRIPTION (provided by applicant): Phosphoinositide recognition by binding proteins and lipid-metabolizing enzymes involves specific interactions with the head group and diacylglycerol backbone, which vary significantly from protein to protein. When a fluorescent probe is introduced into the… More

Intracellular Localization of Protein Prenylation

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Mark J. Brown
Award Amount: $116,150.00
Abstract:
DESCRIPTION (provided by applicant): Isoprenoid diphoshates are key metabolic intermediates for the biosynthesis of many classes of molecules required by single and multicellular organisms. They fulfill a wide variety of cellular functions: components of cell membranes (sterols), electron transport… More

Methylerythritol Phosphate Pathway-Specific Natural Products as Antibacterials

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $592,461.00
Abstract:
DESCRIPTION (provided by applicant): The long-term objective of this project is to identify a new class of antibiotics targeting the methylerythritol phosphate (MEP) pathway, a novel pathway essential for the viability of all Gram-negative and many Gram- p ositive bacteria. Gram-negative bacteria… More

Discovery of Inositol(1,4,5)trisphosphate Receptor Inhibitors

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $93,749.00
Abstract:
DESCRIPTION (provided by applicant): Stroke has become a significant cause of mortality and morbidity among elderly people in industrialized countries. To address the growing burden of health care costs and the immeasurable emotional toll on families as we ll as affected individuals, new… More

Fluorogenic Assays for Measuring the Activity of Ceramidase and Sphingomyelinase

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): Sphingolipids are a class of lipids that have important roles as structural components of cell membranes yet are also key signaling molecules involved in numerous cellular processes such as apoptosis, cell survival, dif ferentiation, motility, and growth. The… More

Methylerythritol Phosphate Pathway Inhibitors Targeting Gram-Negative Infections

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $599,834.00
Abstract:
DESCRIPTION (provided by applicant): The long-term objective of this project is to identify a new class of antibiotics targeting an underexploited pathway essential for the viability of all Gram-negative bacteria, the methylerythritol phosphate (MEP) pathw ay. Gram-negative bacteria are responsible… More

Aptamer-based Glycomics Tools

Award Year / Program / Phase: 2009 / STTR / Phase I
Agency: HHS
Research Institution: GEORGIA STATE UNIVERSITY
Principal Investigator: Binghe Wang
Award Amount: $277,549.00
RI Contact: N/A
Abstract:
DESCRIPTION (provided by applicant): Protein glycosylation plays very important roles in biological processes. However, detecting and differentiating such modifications rapidly is not a trivial issue. Therefore, developing novel tools that allow for the ra pid detection of glycosylation patterns is… More

SBIR Phase I: Near Infrared Substrates for Imaging Autotaxin Activity In Vivo

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: NSF
Principal Investigator: Damian Madan, PhD
Award Amount: $150,000.00
Abstract:
This Small Business Innovation Research (SBIR) Phase I project aims to synthesize ATXRed, an in vivo imaging agent that is specifically activated by the enzymatic activity of autotaxin. Autotaxin is an extracellular enzyme that generates the phospholipid growth factor lysophophatidic acid (LPA). LPA… More

Anti-Phospholipid Multiplex For Pathologic Epitopes

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: HHS
Principal Investigator: Paul O. Neilsen
Award Amount: $248,864.00
Abstract:
DESCRIPTION (provided by applicant): This project will help delineate the true nature of antigens in antiphospholipid syndrome (APS). Application of this knowledge would accelerate the pace of basic and clinical research as well as benefit tens of thousand s of U.S. patients each year. Primary… More

Aptamer-based Glycomics Tools

Award Year / Program / Phase: 2010 / STTR / Phase II
Agency: HHS
Research Institution: Georgia State University
Principal Investigator: Binghe Wang – 404-413-5544
Award Amount: $277,549.00
RI Contact:
Abstract:
DESCRIPTION (provided by applicant): Protein glycosylation plays very important roles in biological processes. However, detecting and differentiating such modifications rapidly is not a trivial issue. Therefore, developing novel tools that allow for the rapid detection of glycosylation patterns is… More

New Approach to Phospholipidosis Prediction

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: HHS
Principal Investigator: Piotr W. Rzepecki – 801-588-0455
Award Amount: $149,884.00
Abstract:
DESCRIPTION (provided by applicant): Drug safety is a major concern for people that taking medicines as well as pharmaceutical companies, regulatory bodies, and basic researchers. Drug induced phospholipidosis (DIPL) is an adverse reaction to cationic amphiphilic drugs (CADs) resulting in excessive… More

SBIR Phase II: Near Infrared Substrates for Imaging Autotaxin Activity In Vivo

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: NSF
Principal Investigator: Damian Madan
Award Amount: $487,812.00
Abstract:
This Small Business Innovation Research (SBIR) Phase II project aims to further develop ATX-Red, an in vivo imaging agent that becomes fluorescent in the presence of the enzyme autotaxin. Autotaxin and its product LPA are involved in numerous biological functions that generally involve cell… More

SBIR PHASE II - 1,136,508YR 1: BASE: 548,090, PARTIALLY FUNDED AT 430,000 (BALANCE TO BE FUNDED: 118,090)YR 2: OPTION: 588,418

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: HHS
Principal Investigator: Paul P. Neilsen – 801-588-0455
Award Amount: $548,090.00
Abstract:
There needs to better biomarkers of alcohol consumption and alcohol induced organ damage. PEth is a nonoxidative, long-lasting metabolite of ethanol consumption and alcohol related organ damage. PEth may also play a role in cell and organ damage. In this contract antibodies are made to PEth for… More