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Company Information:
Name:
RXI PHARMACEUTICALS CORPORATION
Address:
1500 West Park Drive
Suite 210
Westborough, MA 01581-
Suite 210
Westborough, MA 01581-
Located in HUBZone:
No
Woman-Owned:
No
Minority-Owned:
No
URL:
N/A
Phone:
N/A
Award Totals:
Award List:
Orally administered anti-TNFalpha RNAi therapeutic for autoimmune disorders
Award Year / Program / Phase:
2010 / SBIR / Phase I
Agency:
HHS
Principal Investigator:
Anastasia Khvorova
Award Amount:
$597,088.00
Abstract:
DESCRIPTION (provided by applicant): Introduction of small interfering RNAs (siRNAs) into cells results in potent and specific gene silencing by RNA interference (RNAi). Unfortunately, while siRNA-based drugs represent a potentially significant therapeutic
paradigm, the ability to apply this… More
Improving self delivering properties of RNAi compounds through medicinal chemistr
Award Year / Program / Phase:
2011 / SBIR / Phase I
Agency:
HHS
Principal Investigator:
Kevin Fettes – 508-929-3650
Award Amount:
$273,824.00
Abstract:
DESCRIPTION (provided by applicant): Introduction of small interfering RNAs (siRNAs) into cells with transfection reagents results in potent and specific gene silencing by RNA interference (RNAi). Unfortunately, while siRNA-based drugs represent a potentially significant therapeutic paradigm, the… More
Novel RNAi therapy for ALS and other Neurodegenerative Disorders
Award Year / Program / Phase:
2011 / SBIR / Phase I
Agency:
HHS
Principal Investigator:
Anastasia Khvorova – 508-767-3861
Award Amount:
$304,559.00
Abstract:
DESCRIPTION (provided by applicant): Project Summary / Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons in the central nervous system. Degeneration of the motor neurons results in paralysis and eventual death, usually due to… More
Development of sd-rxRNAs as Therapy for Retinoblastoma and Other Malignancies
Award Year / Program / Phase:
2012 / SBIR / Phase I
Agency:
HHS
Principal Investigator:
Pamela Pavco – 508-929-3616
Award Amount:
$292,272.00
Abstract:
DESCRIPTION (provided by applicant): The study of retinoblastoma, a childhood tumor, has provided numerous insights into cancer biology. Perhaps most significantly, this work has revealed that cancers can develop in response to mutations in tumor suppressor genes. Tumor suppressor mutations account… More