Propionic acid is a key intermediate in a variety of human metabolic pathways including catabolism of the amino acids isoleucine, valine, methionine and threonine derived from a protein. a number of inherited metabolic disorders (orphan diseases), as well as nutritional deficiencies of vitamins in a… More

The proposed program relates to the synthesis and evaluationof functionalized tetraazaannulenes (taa) as o organometallics capable of lithium intercalation. the major objective of the program is to show that such functionalized taas can take up lithium ions reversibly and that the potential at which… More

The proposed program relates to the use of deuterated additives in lubricants to reduce wear in limited access or critical use machines. the cost of replacement of the bearings in such machines or the nuisance "cost" of down time in systems with reduced diameter bearings is significantly greater… More

The proposed program relates to the first use of tetraazaannulenes as photosensitizers for photoelectro- chemical cells. a new material is described for forming photosensitized semiconductors with extended life and improved efficiency. the availability of an improved efficiency and reliability soalr… More

The proposed program relates to the development of a universal one-step approach to 1-carbon-2-amino labeling with any isotope of carbon or nitrogen including stable ([13]c, [15]n), radio ([14]c), and positron-emitting nuclides ([11]c, [13]n). given the increased involvement of amino acid technology… More

This project evaluates the potential of a new class of cathode catalysts to improve the safety and the performance of high-rate li/socl(2) batteries. a safer li/socl(2) battery with improved capacity, rate capability and voltage delay provides a practical long-life energy/power density lithium-based… More

The proposed program relates to the evaluation of the potential of a new class of cathode materials for improved performance/energydensity lithium secondary batteries. an improved secondary battery will provide the navy with a safe and reliable power source for portable communication systems, remote… More

The proposed program relates to the evaluation of a new class of cathode materials for improved performance/ energy density lithium secondary batteries. an improved secondary battery will provide the navy with a safe and reliable power source for portable communication system, remote sensors, and… More

The proposed program relates to the synthesis of (13)c multilabeled cholesterol and -sitosterol as potential diagnostic agents. hypercholesterolemia has been implicated as a primary risk factor in coronary heart disease yet major questions regarding cholesterol absorption, transport, reverse… More

The proposed program relates to the investigation of the properties of the passivating film on the metal in alkali metal-oxyhalide systems when the oxyhalide contains a valve metal solute. the purpose of addition of the valve metal is to change the passivating film to a continuous thin conductive… More

The use of (13)c-labeled tracers in nutritional status assessment has recently received increased attention. breath tests using low-cost (13)c-labeled tracers are emerging, along with breath tests in general in metabolic monitoring, as useful clinical tools in the study of nutritional disorders in a… More

In the proposed program the performance and discharge capacity off lithium cells with carbon cathodes and 1, 3-dioxolane-based electrolytes will be determined. initial data show that this li/diox/c cell will be a primary lithium battery with the rate capability and discharge capacity of a li/soc12… More

The program is addressed to the development of non-invasive methods for evaluation of nutritional status and body composition in pediatric patients. we will examine the kinetics of (13)co2 exhalation in breath after bolus administration of nah(13)co3 and then calculate significant parameters from… More

The proposed program relates to the evaluation of a new cathode catalyst in dis-type li/soc12 cells. this new ca catalyst has been shown to change the cathode reaction mechanism and to increase both cathode rate (factor of ten) and capacity (factor of at least two) in bobbin-type li/soc12 cells. the… More

The program addresses the development of a noninvasive method for the evaluation of peptide absorption, transport, and metabolism. when carbon-13 labeled peptides exemplifiedby leucylleucine are administered orally, they are absorbed,transported to the liver, transaminated, and oxidated, affording… More

The proposed program relates to the identification of a mixed solvent electrolyte capable of extending the power density, cycle life and useful temperature range of a lithium secondary battery. cells with electrolytes containing a mixture of a cyclic ether and an alkyl urea will be tested. the… More

The proposed program relates to the development of a laser-based method to clad metals with silicon-based ceramics. the ceramic layer is to be intimately bonded to the metal surface by in situ ceramic formation and reaction with the metal substrate. such ceramiccladded metals will be low-cost,… More

The objective of the proposed program is to initially characterize the performance of a new class of calcium cellswhich use an organic catholyte. based on initial data, thisclass of cells will have the energy and power densities of bobbin-type li/soc12 cells. the major advantages of this new class… More

The program is to develop a method for the formation of a thin ceramic coating on implanted electronic devices used inneurostimulation which coating will afford the device with enhanced protection from corrosion by body fluids and tissues. the coating is to be formed in a new laser-based process in… More

The objective of the proposed program is to demonstrate the technical feasibility of increasing the thermal tolerance and metal wettability of carbon composite materials through the application of a titanium carbide ceramic to their surface. the application process will be laser-based and will… More

The objective of the proposed program is to investigate the technical feasibility of applying an electrochemical process to the in situ dehalogenation of hazardous wastes found in landfills and in soils contaminated by leaks or spills. preliminary work by tracer has shown that an electrochemical… More

The objective of the phase i program is to demonstrate the technical feasibility of the use of a high tc superconducting wire as a sensor in nondestructive evaluation systems. the wire will be tested for sensitivityto magnetic field flux and to infrared irradiance. the wirewill consist of a copper… More

The objective of the phase i program is to demonstrate the technical feasibility of developing a low-thermal-conductivity connector using a laser-based process. the connector will consist of a graphite core, a metal interphase layer, and a high-tc superconducting ceramic surface layer. lengths of… More

The objective of the Phase I program is to demonstrate the feasibility of developing a cell in annular design which meets the Navy's mission needs. This cell is to utilize Li/CFx chemistry to take advantage of the high energy density and improved safety of this chemistry. In the Phase I program, ECO… More