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THE PROGRAM ADDRESSES THE DEVELOPMENT OF A NONINVASIVE METHOD FOR THE…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4897
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4897
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ECO ENERGY CONVERSION
(d/b/a Tracer Technologies, In Somerville, MA 02145
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: THE PROGRAM ADDRESSES THE DEVELOPMENT OF A NONINVASIVE METHOD FOR THE EVALUATION OF PEPTIDE ABSORPTION, TRANSPORT, AND METABOLISM.
Agency: HHS
Contract: N/A
Award Amount: $37,000.00
 

Abstract:

THE PROGRAM ADDRESSES THE DEVELOPMENT OF A NONINVASIVE METHOD FOR THE EVALUATION OF PEPTIDE ABSORPTION, TRANSPORT, AND METABOLISM. WHEN CARBON-13 LABELED PEPTIDES EXEMPLIFIEDBY LEUCYLLEUCINE ARE ADMINISTERED ORALLY, THEY ARE ABSORBED,TRANSPORTED TO THE LIVER, TRANSAMINATED, AND OXIDATED, AFFORDING 13CO2 AS A METABOLITE, THE KINETICS OF 13CO2 PRODUCTION CAN BE MEASURED IN BREATH AND QUANTIFIED BY NON- COMPARTMENTAL ANALYSIS. THIS STUDY WILL DEVELOP A BREATH TEST INDEX FOR DIPEPTIDE METABOLISM THAT WILL DIFFERENTIATE BETWEEN NORMAL CONTROLS AND CASES PRESENTING WITH DISEASES WHICH HAVE DERANGED NORMAL PROTEIN DYNAMICS. THE PEPTIDE BREATH TEST WILL BE CONFIGURED TO TAKE ADVANTAGE OF PORTABLEINFRARED INSTRUMENTATION FOR MEASURING STABLE ISOTOPES IN BREATH. IT WILL BE VALIDATED AGAINST CONVENTIONAL OBJECTIVEMEASURES OF PROTEIN BALANCE WITH A VIEW TOWARDS ESTABLISHINGITS UTILITY BOTH AS A DIAGNOSTIC TOOL AND AS A MANAGEMENT AID IN THE TREATMENT OF NUTRITIONAL DISORDERS. THE PEPTIDE BREATH TEST WILL ALSO BE STUDIED AS A MEANS TO OBSERVING INTERINDIVIDUAL VARIATIONS IN GASTRIC EMPTYING AND TRANSIT TIME IN CONNECTION WITH PATTERNS OF DIETARY INTAKE.

Principal Investigator:

Alfred m ajami
PRINCIPAL INVESTIGATOR
6177766410

Business Contact:

Small Business Information at Submission:

Tracer Technologies Inc
20 Assembly Square Drive Somerville, MA 02145

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No