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Low-Cost Production of Engineered Proteins in Transgenic Plants

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
78062
Program Year/Program:
2006 / STTR
Agency Tracking Number:
A064-015-0242
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
EDENSPACE SYSTEMS CORPORATION
210 N 21st Street, Suite B Purcellville, VA 20132-3026
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2006
Title: Low-Cost Production of Engineered Proteins in Transgenic Plants
Agency / Branch: DOD / ARMY
Contract: W911NF-06-C-0103
Award Amount: $99,649.00
 

Abstract:

Plants provide an attractive platform for the production of recombinant proteins because they require significantly less capital investment than microbial fermentation systems and can be easily scaled up to produce additional protein. Edenspace proposes to develop a versatile plant expression system with tobacco to produce and purify proteins with therapeutic and industrial purposes. The gene expression cassette to be developed will include a molecular tag to simplify purification of the recombinant protein before being cleaved in order to preserve the biological activity of the protein. To demonstrate this system, Edenspace has created transgenic tobacco with its research partner at Michigan State University, Dr. Mariam Sticklen, expressing the human secretory leukocyte protease inhibitor (SLPI) protein. SLPI is well known for its anti-microbial, wound healing and anti-inflammatory activities, and through this project Edenspace will demonstrate the effectiveness of producing active SLPI in tobacco.

Principal Investigator:

David Lee
7039618700
lee@edenspace.com

Business Contact:

Bruce Ferguson
President/CEO
7039618700
ferguson@edenspace.com
Small Business Information at Submission:

EDENSPACE SYSTEMS CORP.
3810 Concorde Parkway Dulles, VA 20151

EIN/Tax ID: 541916832
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
MICHIGAN STATE UNIV.
301 Administration Building
Lansing, MI 48824
Contact: Susan Titus
Contact Phone: (517) 353-9751
RI Type: Nonprofit college or university