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A FIBEROPTIC PROBE FOR IN VIVO NEUROTRANSMITTER ANALYSIS
- Small Business Information
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Woman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
- Phase 1
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Fiscal Year: 1990Title: A FIBEROPTIC PROBE FOR IN VIVO NEUROTRANSMITTER ANALYSISAgency: HHSContract: N/AAward Amount: $49,974.00
Abstract:
MICRODIALYSIS (MD) IS AN INCREASINGLY IMPORTANT TOOL FOR SAMPLING THE EXTRACELLULAR FLUID OF SPECIFIC REGIONS OF THE BRAIN. REAL-TIME, DIRECT ANALYSIS OF THE MICRODIALYSATEWOULD BE ADVANTAGEOUS FOR STUDYING DYNAMIC CHANGES IN BRAIN CHEMISTRY AS A FUNCTION OF BEHAVIOR OR IN RESPONSE TO EXPERIMENTAL PARADIGMS OR TRAUMA. THE RESEARCH WILL DEVELOP A SURFACE-ENHANCED RAMAN SPECTROSCOPY (SERS) PROBE ON THE TIP OF AN OPTIC FIBER IN DIMENSIONS SUITABLE FOR INSERTION INTO AN IN VIVO MICRODIALYSIS CANNULA. THE SERS/MD PROBE WILL ENABLE IN VIVO ANALYSIS OF NEUROTRANSMITTERS OR OTHER SUBSTANCES IN BRAIN EXTRACELLULAR FLUID BY SERS TECHNIQUES. THE PHASE I OBJECTIVES ARE TO FABRICATE OPTICAL FIBERS WITH SERS SUBSTRATES, COUPLE THEM WITH MICRODIALYSIS CANNULAS, AND DEMONSTRATE DOPAMINE ANALYSIS DURING MICRODIALYSIS FROM A SIMULATED BRAIN EXTRACELLULAR FLUID. SUCCESSFUL DEMONSTRATION OF THE FEASIBILITY OF A SERS/MD PROBE WILL PROVIDE A FOUNDATION FOR PHASE II WORK TO EVALUATE THE PROBEDURING IN VIVO MICRODIALYSIS EXPERIMENTS AND TO DEVELOP A PROTOTYPE SERS/MD PROBE AND INSTRUMENTATION PACKAGE FOR USE IN ACADEMIC, CLINICAL, AND PHARMACEUTICAL NEUROCHEMISTRY LABORATORIES.Small Business Information at Submission:Principal Investigator:
Lois S Robblee
6177699450Business Contact:
Eic Laboratories Inc
111 Downey St Norwood, MA 02062EIN/Tax ID: 042497074DUNS: N/ANumber of Employees: N/AWoman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
Award Information
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Agency: Department of Health and Human Services |
Branch: N/A |
Award ID: 14044 |
Program Year/Program: 1990 / SBIR |
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Agency Tracking Number: 14044 |
Solicitation Year: N/A |
Solicitation Topic Code: N/A |
Solicitation Number: N/A |