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A FIBEROPTIC PROBE FOR IN VIVO NEUROTRANSMITTER ANALYSIS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
14044
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
14044
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
EIC LABORATORIES, INC.
111 DOWNEY ST NORWOOD, MA 02062-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1990
Title: A FIBEROPTIC PROBE FOR IN VIVO NEUROTRANSMITTER ANALYSIS
Agency: HHS
Contract: N/A
Award Amount: $49,974.00
 

Abstract:

MICRODIALYSIS (MD) IS AN INCREASINGLY IMPORTANT TOOL FOR SAMPLING THE EXTRACELLULAR FLUID OF SPECIFIC REGIONS OF THE BRAIN. REAL-TIME, DIRECT ANALYSIS OF THE MICRODIALYSATEWOULD BE ADVANTAGEOUS FOR STUDYING DYNAMIC CHANGES IN BRAIN CHEMISTRY AS A FUNCTION OF BEHAVIOR OR IN RESPONSE TO EXPERIMENTAL PARADIGMS OR TRAUMA. THE RESEARCH WILL DEVELOP A SURFACE-ENHANCED RAMAN SPECTROSCOPY (SERS) PROBE ON THE TIP OF AN OPTIC FIBER IN DIMENSIONS SUITABLE FOR INSERTION INTO AN IN VIVO MICRODIALYSIS CANNULA. THE SERS/MD PROBE WILL ENABLE IN VIVO ANALYSIS OF NEUROTRANSMITTERS OR OTHER SUBSTANCES IN BRAIN EXTRACELLULAR FLUID BY SERS TECHNIQUES. THE PHASE I OBJECTIVES ARE TO FABRICATE OPTICAL FIBERS WITH SERS SUBSTRATES, COUPLE THEM WITH MICRODIALYSIS CANNULAS, AND DEMONSTRATE DOPAMINE ANALYSIS DURING MICRODIALYSIS FROM A SIMULATED BRAIN EXTRACELLULAR FLUID. SUCCESSFUL DEMONSTRATION OF THE FEASIBILITY OF A SERS/MD PROBE WILL PROVIDE A FOUNDATION FOR PHASE II WORK TO EVALUATE THE PROBEDURING IN VIVO MICRODIALYSIS EXPERIMENTS AND TO DEVELOP A PROTOTYPE SERS/MD PROBE AND INSTRUMENTATION PACKAGE FOR USE IN ACADEMIC, CLINICAL, AND PHARMACEUTICAL NEUROCHEMISTRY LABORATORIES.

Principal Investigator:

Lois S Robblee
6177699450

Business Contact:

Small Business Information at Submission:

Eic Laboratories Inc
111 Downey St Norwood, MA 02062

EIN/Tax ID: 042497074
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No