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PACING, SENSING AND DEFIBRILLATION ELECTRODE COATINGS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60363
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
HL071395
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
EIC LABORATORIES, INC.
111 DOWNEY ST NORWOOD, MA 02062-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: PACING, SENSING AND DEFIBRILLATION ELECTRODE COATINGS
Agency: HHS
Contract: 1R43HL071395-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): The development of low-polarization coatings for cardiac pacing, sensing and defibrillation electrodes is proposed. The coatings address the needs of the cardiac rhythm management industry in the development of high-impedance, low-polarization pacing electrodes, low impedance defibrillation electrodes, and post-stimulus sensing methodologies for rate adaptive pacing employing a single pacing and sensing electrode. The coatings are reduction-oxidation (redox) materials with tailored surface morphologies that maximize low-polarization charge injection in thin (<150 nm), physically and chemically robust coatings. Innovations in the chemistry and deposition of the redox coatings are proposed that will enhance in vivo chemical and physical stability. The coatings will accommodate organic overlayers, such as PEG and steroid eluting membranes, and allow chemical surface modification to improve biocompatibility and moderate fibrotic tissue encapsulation. In Phase I, the coatings would be applied to endocardial pacing and defibrillation electrodes. In vitro characterization would include polarization during pacing and defibrillation, impedance, stability in biomolecule containing physiologic media and stability under mechanical challenge. The relationship between composition and morphology of the coatings and their performance as pacing and defibrillation electrodes would be established. In Phase I, organic surface treatments would be introduced and testing to establish chronic in vivo and functionally stability undertaken. PROPOSED COMMERCIAL APPLICATION: A low-polarization coating for cardiac pacing, defibrillation and sensing electrodes has commercial potential in an extremely large market. Besides cardiac applications, the coatings will be suitable for deep-brain stimulation, cortical stimulation and recording in functional electrical stimulation for sensory and motor prostheses, and vagus nerve stimulation for epilepsy. These are growing markets in which the use of the coatings will have clear clinical benefit with significant commercial potential.

Principal Investigator:

Stuart F. Cogan
7817699450
SCOGAN@EICLABS.COM

Business Contact:

David Rauh
7817699450
DRAUH@EICLABS.COM
Small Business Information at Submission:

EIC LABORATORIES, INC.
EIC LABORATORIES, INC. 111 DOWNEY ST NORWOOD, MA 02062

EIN/Tax ID: 042497074
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No