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NEUTRON DETECTORS FOR MACROMOLECULAR CRYSTALLOGRAPHY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
70768
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
RR018651
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
EIC LABORATORIES, INC.
111 DOWNEY ST NORWOOD, MA 02062-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: NEUTRON DETECTORS FOR MACROMOLECULAR CRYSTALLOGRAPHY
Agency: HHS
Contract: 1R43RR018651-01A1
Award Amount: $99,997.00
 

Abstract:

DESCRIPTION (provided by applicant): Structure-aided drug design requires state-of-the-art crystallography to understand the relationship of protein structure to its function in disease causing organism to lead the way in designing novel effective drugs without any side effects. Neutron diffraction provides a unique approach to investigate the structural biology by determining the position of hydrogen atoms, which are critical to structural stability and effective function but are unobservable by X-rays. The objective of the proposed program is to develop a new solid-state, large-area, and position sensitive neutron detector based on boron-doped amorphous selenium for macromolecular neutron crystallography. The detector would offer high spatial resolution, high detection efficiency, fast response and reset time, excellent gamma discrimination, and high radiation hardness. The proposed detector would be inexpensive for industrial mass production. The Phase I project will focus on zone-purification of Se precursors, synthesis of heavily B-doped (up to 32.4 atomic %) a-Se (As, CI) alloys, detector design and fabrication, and performance evaluation at Spallation Neutron Source (SNS), Oak Ridge National Laboratory (ORNL). The developed detectors would find widespread use in neutron diffraction for structural biology, neutron scattering research, nuclear non-proliferation and in high priority national program of Homeland Security.

Principal Investigator:

Krishna C. Mandal
7817699450
KMANDAL@EICLABS.COM

Business Contact:

A. Makrides
7817699450
DRAUH@EICLABS.COM
Small Business Information at Submission:

EIC LABORATORIES, INC.
EIC LABORATORIES, INC. 111 DOWNEY ST NORWOOD, MA 02062

EIN/Tax ID: 042497074
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No