USA flag logo/image

An Official Website of the United States Government

Semiconductor Nanocrystals for Biomedical Imaging

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
75857
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
AA015644
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
EIC LABORATORIES, INC.
111 DOWNEY ST NORWOOD, MA 02062-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2005
Title: Semiconductor Nanocrystals for Biomedical Imaging
Agency: HHS
Contract: 1R43AA015644-01
Award Amount: $199,889.00
 

Abstract:

The principal objective in Phase I is to demonstrate methodologies for the stabilization and functionalization of luminescent nanoparticles (quantum dots, QDs) to be used in cellular imaging. This will be achieved by encapsulating QDs in two different types of water-soluble polymer delivery vehicles. Both types of polymer will eventually be functionalized with specific targeting ligands in order to facilitate imaging of selected cellular targets. The physicochemical properties that make QDs well suited for such imaging applications include: their quantum yields, small size, narrow emission wavelengths which effect little or no spectral overlap among multiple-size QD tags, their photostability, and their very high absorption efficiencies which obviate the need for high power requirements for excitation. In Phase I, we will synthesize the polymers and use them to encapsulate QDs of defined diameter. Each nanoparticle complex will be characterized in terms of luminescence profile, quantum yield, photostability, and extinction coefficient. These properties will be examined in a variety of environments to determine any pH- or solvent dependent aspects of fluorescence behavior. Both types of encapsulated nanoparticle probes will be used to transfect cultured mammalian cells in order to assess QD luminescence in a physiological milieu.

Principal Investigator:

Fei Wang
7817699450
feiwang@eiclabs.com

Business Contact:

R. Rauh
7817699450
DRAUH@EICLABS.COM
Small Business Information at Submission:

Eic Laboratories, Inc.
Eic Laboratories, Inc. 111 Downey St Norwood, MA 02062

EIN/Tax ID: 042497074
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No