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Rapid determination of complement activation in the battlefield

Award Information

Agency:
Department of Defense
Branch:
Office of the Secretary of Defense
Award ID:
76508
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
O043-H09-3053
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
EIC LABORATORIES, INC.
111 DOWNEY ST NORWOOD, MA 02062-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2005
Title: Rapid determination of complement activation in the battlefield
Agency / Branch: DOD / OSD
Contract: W81XWH-05-C-0072
Award Amount: $99,997.00
 

Abstract:

The objective of this program is to develop an antibody microarray to facilitate the rapid evaluation of complement activation in injured personnel in the battlefield. Soldiers in the battlefield may sustain multiple types of injury, including trauma, hemorrhage, shock, ischemia, burn, and exposure to toxic substances. These conditions are associated with varying degrees of complement activation, which in turn may lead to further deterioration, if left untreated. Moreover, complement is central to normal physiological defenses against microbial infections, and knowledge of the extent of complement activation will aid in determining its proportional inhibition. The proposed antibody microarray would aid the health care professional to evaluate various parameters in injured personnel, including the extent of complement activation, the specific complement pathway that is activated, whether complement inhibitors should be administered, the type of inhibitor to administer, depending on the complement pathway involved, and the dose of inhibitor to be administered. At EIC Laboratories we have developed methods for fabricating immunological electrode sensors based on antibodies immobilized in a hydrous 3-dimensional iridium oxide matrix. In the Phase I program we will construct a prototype antibody array for the electrochemical detection of two different complement proteins.

Principal Investigator:

Michael S. Wilson
Senior Scientist
7817699450
mwilson@eiclabs.com

Business Contact:

R. D. Rauh
President
7817699450
drauh@eiclabs.com
Small Business Information at Submission:

EIC LABORATORIES, INC.
111 Downey Street Norwood, MA 02062

EIN/Tax ID: 042497074
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No