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Rapid determination of complement activation in the battlefield

Award Information

Agency:
Department of Defense
Branch:
Office of the Secretary of Defense
Award ID:
76509
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
O2-0355
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
EIC LABORATORIES, INC.
111 DOWNEY ST NORWOOD, MA 02062-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2005
Title: Rapid determination of complement activation in the battlefield
Agency / Branch: DOD / OSD
Contract: W81XWH-05-C-0072
Award Amount: $749,981.00
 

Abstract:

The objective of this program is to develop a portable biosensor system to facilitate the rapid evaluation of complement activation in injured personnel. Traumatic blood loss and tissue damage resulting from civilian or battlefield trauma leads to complement activation that, if left untreated, contributes to further tissue damage, shock, respiratory distress syndrome and multiorgan failure. Appropriate inhibition of complement activation is expected to limit tissue damage in such cases. However, since complement is central in the protection against infectious agents, extensive inhibition may lead to overwhelming infection and sepsis. The ability to determine and monitor the extent of complement activation in injured personnel is, therefore, the critical first step for providing appropriate inhibition treatment. In Phase I we successfully demonstrated the feasibility of our sensor technology by measuring two key complement proteins. In Phase II, methods developed in the Phase I will be refined and expanded through optimization of sensor and assay design, expansion of the Phase I sensor to a greater number of assays, and the development of a robust, reliable and portable multianalyte assaying system.

Principal Investigator:

Michael S. Wilson
Senior Scientist
7817699450
mwilson@eiclabs.com

Business Contact:

R. D. Rauh
President
7817699450
drauh@eiclabs.com
Small Business Information at Submission:

EIC LABORATORIES, INC.
111 Downey Street Norwood, MA 02062

EIN/Tax ID: 042497074
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No